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Developing predictors of the health benefits of exercise for individuals

Objective

Physical activity is a powerful lifestyle factor that on average reduces risk for development of diabetes and cardiovascular disease. Nevertheless, we have demonstrated that following supervised endurance exercise training, 20% of subjects show no change in fitness and 30% demonstrate no improvement in insulin sensitivity or worse-still an adverse response. Our concept is that by using molecular profiling of blood/muscle samples we will develop personalised lifestyle intervention tools. Further, revealing the biological basis for a variable metabolic or cardiovascular response to exercise will enable us to propose new targets and biomarkers for drug discovery efforts directly in humans. Using our established OMICS approaches (RNA, DNA and Metabo-) we will generate classifiers that predict the responses to exercise-therapy (fitness and insulin sensitivity). Classifier generation is a statistical strategy for diagnosis or prognosis. Critically, we have a large human tissue biobank, including subjects with insulin-resistance; young to elderly males and females, as well as twins. Our SME partners have significant intellectual property and capacity in the field of bio-prediction, with a proven track-record of collaboration with the team and product development. We will add to the diversity of our biobank by carrying-out an exercise intervention study using a novel time-efficient strategy that we have recently proven to be effective in reducing insulin resistance in sedentary young people and in middle aged obese subjects. A time-efficient protocol is a critical as lack-of-time is a key reason for not maintaining physical activity levels. Finally, we have a novel out-bred rodent model that replicates high and low exercise training responses and we will establish its suitability for future drug screening purposes. Because of these substantial pre-existing resources we believe that our project has a very high probability of delivering on its goals of improving the healthcare of European citizens

Field of science

  • /medical and health sciences/clinical medicine/cardiology/cardiovascular diseases

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

KAROLINSKA INSTITUTET
Address
Nobels Vag 5
17177 Stockholm
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 542 072
Administrative Contact
Pille Ann Härmat (Mrs.)

Participants (11)

MEDICAL PROGNOSIS INSTITUTE AS
Denmark
EU contribution
€ 854 349,53
Address
Venlighedsvej 1
2970 Horsholm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Steen Knudsen (Dr.)
THE UNIVERSITY OF NOTTINGHAM
United Kingdom
EU contribution
€ 605 232
Address
University Park
NG7 2RD Nottingham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Cartledge (Mr.)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 601 200
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ivan Kristoffersen (Mr.)
JYVASKYLAN YLIOPISTO
Finland
EU contribution
€ 468 000
Address
Seminaarinkatu 15
40100 Jyvaskyla
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Keijo Hakkinen (Prof.)
UNIVERSIDAD DE LAS PALMAS DE GRAN CANARIA
Spain
EU contribution
€ 500 400
Address
C/ Juan De Quesada 30
35001 Las Palmas De Gran Canaria
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Javier Rodríguez Sosa (Mr.)
DUKE UNIVERSITY
United States
EU contribution
€ 27 000
Address
Allen Building 207
27708 Durham Nc
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Cynthia Case (Ms.)
XRGENOMICS LTD
United Kingdom
EU contribution
€ 484 396
Address
Clinton Avenue Regent House
NG5 1AZ Nottingham
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Liam Good (Dr.)
LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE

Participation ended

United States
EU contribution
€ 458 400
Address
Himes Hall 202
70803 Baton Rouge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Claude Bouchard (Dr.)
LOUGHBOROUGH UNIVERSITY

Participation ended

United Kingdom
EU contribution
€ 370 504,92
Address
Ashby Road
LE11 3TU Loughborough
Activity type
Higher or Secondary Education Establishments
Administrative Contact
James Timmons (Prof.)
MCMASTER UNIVERSITY

Participation ended

Canada
EU contribution
€ 20 549,12
Address
1280 Main St West
L8S 4L8 Hamilton
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kathy Charters (Ms.)
THE UNIVERSITY OF BIRMINGHAM

Participation ended

United Kingdom
EU contribution
€ 66 302,43
Address
Edgbaston
B15 2TT Birmingham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
May Chung (Ms.)