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Developing predictors of the health benefits of exercise for individuals

Cel

Physical activity is a powerful lifestyle factor that on average reduces risk for development of diabetes and cardiovascular disease. Nevertheless, we have demonstrated that following supervised endurance exercise training, 20% of subjects show no change in fitness and 30% demonstrate no improvement in insulin sensitivity or worse-still an adverse response. Our concept is that by using molecular profiling of blood/muscle samples we will develop personalised lifestyle intervention tools. Further, revealing the biological basis for a variable metabolic or cardiovascular response to exercise will enable us to propose new targets and biomarkers for drug discovery efforts directly in humans. Using our established OMICS approaches (RNA, DNA and Metabo-) we will generate classifiers that predict the responses to exercise-therapy (fitness and insulin sensitivity). Classifier generation is a statistical strategy for diagnosis or prognosis. Critically, we have a large human tissue biobank, including subjects with insulin-resistance; young to elderly males and females, as well as twins. Our SME partners have significant intellectual property and capacity in the field of bio-prediction, with a proven track-record of collaboration with the team and product development. We will add to the diversity of our biobank by carrying-out an exercise intervention study using a novel time-efficient strategy that we have recently proven to be effective in reducing insulin resistance in sedentary young people and in middle aged obese subjects. A time-efficient protocol is a critical as lack-of-time is a key reason for not maintaining physical activity levels. Finally, we have a novel out-bred rodent model that replicates high and low exercise training responses and we will establish its suitability for future drug screening purposes. Because of these substantial pre-existing resources we believe that our project has a very high probability of delivering on its goals of improving the healthcare of European citizens

Zaproszenie do składania wniosków

FP7-HEALTH-2011-two-stage
Zobacz inne projekty w ramach tego zaproszenia

System finansowania

CP-FP - Small or medium-scale focused research project
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Koordynator

KAROLINSKA INSTITUTET
Adres
Nobels Vag 5
17177 Stockholm
Szwecja
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Higher or Secondary Education Establishments
Wkład UE
€ 1 542 072
Kontakt administracyjny
Pille Ann Härmat (Mrs.)

Uczestnicy (11)

MEDICAL PROGNOSIS INSTITUTE AS
Dania
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2970 Horsholm
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
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Steen Knudsen (Dr.)
THE UNIVERSITY OF NOTTINGHAM
United Kingdom
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€ 605 232
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University Park
NG7 2RD Nottingham
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Higher or Secondary Education Establishments
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Paul Cartledge (Mr.)
KOBENHAVNS UNIVERSITET
Dania
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€ 601 200
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Norregade 10
1165 Kobenhavn
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Higher or Secondary Education Establishments
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Ivan Kristoffersen (Mr.)
JYVASKYLAN YLIOPISTO
Finlandia
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€ 468 000
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Seminaarinkatu 15
40100 Jyvaskyla
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Higher or Secondary Education Establishments
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Keijo Hakkinen (Prof.)
UNIVERSIDAD DE LAS PALMAS DE GRAN CANARIA
Hiszpania
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€ 500 400
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C/ Juan De Quesada 30
35001 Las Palmas De Gran Canaria
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Javier Rodríguez Sosa (Mr.)
DUKE UNIVERSITY
Stany Zjednoczone
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€ 27 000
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Allen Building 207
27708 Durham Nc
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Higher or Secondary Education Establishments
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Cynthia Case (Ms.)
XRGENOMICS LTD
United Kingdom
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€ 484 396
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Clinton Avenue Regent House
NG5 1AZ Nottingham
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Liam Good (Dr.)
LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE

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€ 458 400
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Himes Hall 202
70803 Baton Rouge
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Claude Bouchard (Dr.)
LOUGHBOROUGH UNIVERSITY

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United Kingdom
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€ 370 504,92
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Ashby Road
LE11 3TU Loughborough
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James Timmons (Prof.)
MCMASTER UNIVERSITY

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Kanada
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L8S 4L8 Hamilton
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Kathy Charters (Ms.)
THE UNIVERSITY OF BIRMINGHAM

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€ 66 302,43
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Edgbaston
B15 2TT Birmingham
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May Chung (Ms.)