Obiettivo Physical activity is a powerful lifestyle factor that on average reduces risk for development of diabetes and cardiovascular disease. Nevertheless, we have demonstrated that following supervised endurance exercise training, 20% of subjects show no change in fitness and 30% demonstrate no improvement in insulin sensitivity or worse-still an adverse response. Our concept is that by using molecular profiling of blood/muscle samples we will develop personalised lifestyle intervention tools. Further, revealing the biological basis for a variable metabolic or cardiovascular response to exercise will enable us to propose new targets and biomarkers for drug discovery efforts directly in humans. Using our established OMICS approaches (RNA, DNA and Metabo-) we will generate classifiers that predict the responses to exercise-therapy (fitness and insulin sensitivity). Classifier generation is a statistical strategy for diagnosis or prognosis. Critically, we have a large human tissue biobank, including subjects with insulin-resistance; young to elderly males and females, as well as twins. Our SME partners have significant intellectual property and capacity in the field of bio-prediction, with a proven track-record of collaboration with the team and product development. We will add to the diversity of our biobank by carrying-out an exercise intervention study using a novel time-efficient strategy that we have recently proven to be effective in reducing insulin resistance in sedentary young people and in middle aged obese subjects. A time-efficient protocol is a critical as lack-of-time is a key reason for not maintaining physical activity levels. Finally, we have a novel out-bred rodent model that replicates high and low exercise training responses and we will establish its suitability for future drug screening purposes. Because of these substantial pre-existing resources we believe that our project has a very high probability of delivering on its goals of improving the healthcare of European citizens Campo scientifico medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesgeneticsDNAmedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesclinical medicinecardiologycardiovascular diseasesnatural sciencesbiological sciencesgeneticsRNA Programma(i) FP7-HEALTH - Specific Programme "Cooperation": Health Argomento(i) HEALTH.2011.2.4.2-2 - Evaluation and validation studies of clinically useful biomarkers in prevention and management of cardiovascular diseases HEALTH.2011.2.4.3-3 - Molecular and physiological effects of lifestyle factors on diabetes/obesity Invito a presentare proposte FP7-HEALTH-2011-two-stage Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore KAROLINSKA INSTITUTET Contributo UE € 1 542 072,00 Indirizzo Nobels Vag 5 17177 Stockholm Svezia Mostra sulla mappa Regione Östra Sverige Stockholm Stockholms län Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Pille Ann Härmat (Mrs.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (11) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto MEDICAL PROGNOSIS INSTITUTE AS Danimarca Contributo UE € 854 349,53 Indirizzo VENLIGHEDSVEJ 1 2970 HORSHOLM Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Steen Knudsen (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato THE UNIVERSITY OF NOTTINGHAM Regno Unito Contributo UE € 605 232,00 Indirizzo University Park NG7 2RD Nottingham Mostra sulla mappa Regione East Midlands (England) Derbyshire and Nottinghamshire Nottingham Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Paul Cartledge (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato KOBENHAVNS UNIVERSITET Danimarca Contributo UE € 601 200,00 Indirizzo NORREGADE 10 1165 Kobenhavn Mostra sulla mappa Regione Danmark Hovedstaden Byen København Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Ivan Kristoffersen (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato JYVASKYLAN YLIOPISTO Finlandia Contributo UE € 468 000,00 Indirizzo SEMINAARINKATU 15 40100 Jyvaskyla Mostra sulla mappa Regione Manner-Suomi Länsi-Suomi Keski-Suomi Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Keijo Hakkinen (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSIDAD DE LAS PALMAS DE GRAN CANARIA Spagna Contributo UE € 500 400,00 Indirizzo C/ Juan de Quesada 30 35001 Las Palmas De Gran Canaria Mostra sulla mappa Regione Canarias Canarias Gran Canaria Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Javier Rodríguez Sosa (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato DUKE UNIVERSITY Stati Uniti Contributo UE € 27 000,00 Indirizzo ALLEN BUILDING 207 27708 Durham Nc Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Cynthia Case (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato XRGENOMICS LTD Regno Unito Contributo UE € 484 396,00 Indirizzo CLINTON AVENUE REGENT HOUSE NG5 1AZ NOTTINGHAM Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Liam Good (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE Partecipazione conclusa Stati Uniti Contributo UE € 458 400,00 Indirizzo HIMES HALL 202 70803 Baton Rouge Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Claude Bouchard (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato LOUGHBOROUGH UNIVERSITY Partecipazione conclusa Regno Unito Contributo UE € 370 504,92 Indirizzo ASHBY ROAD LE11 3TU Loughborough Mostra sulla mappa Regione East Midlands (England) Leicestershire, Rutland and Northamptonshire Leicestershire CC and Rutland Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo James Timmons (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato MCMASTER UNIVERSITY Partecipazione conclusa Canada Contributo UE € 20 549,12 Indirizzo 1280 MAIN ST WEST L8S 4L8 Hamilton Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Kathy Charters (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato THE UNIVERSITY OF BIRMINGHAM Partecipazione conclusa Regno Unito Contributo UE € 66 302,43 Indirizzo Edgbaston B15 2TT Birmingham Mostra sulla mappa Regione West Midlands (England) West Midlands Birmingham Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo May Chung (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato