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Recruitment and activation of brown adipocytes as preventive and curative therapy for type 2 diabetes

Objective

The DIABAT project will employ knowledge of the function, dysfunction and physiological regulation of brown adipocytes to develop innovative therapeutic and preventive strategies for type 2 diabetes. Brown adipose tissue (BAT) is currently a worldwide recognized target to combat obesity and diabetes due to last years re-discovery of functional BAT in adult humans by several of the members of the DIABAT network (van Marken LIchtenbelt et al., N. Engl. J. Med. 360, 1500, 2009; Virtanen…, Enerbäck & Nuutila, N. Engl. J. Med. 360, 1518, 2009) along with sharp rise in insight in cellular, genetic, and regulatory mechanisms from animal studies. Therefore, the DIABAT project aims at recruiting and re-activating endogenous energy-dissipating BAT as a preventive and/or remedial measure for weight and blood sugar control in obesity-related type 2 diabetes (“diabesity”), thereby halting or preventing destruction and facilitating recovery of pancreatic beta-cells under diabetic conditions.

Field of science

  • /medical and health sciences/clinical medicine/endocrinology/diabetes

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Address
Im Neuenheimer Feld 280
69120 Heidelberg
Germany
Activity type
Research Organisations
EU contribution
€ 566 182
Administrative Contact
Ina Wiest (Dr.)

Participants (20)

FYZIOLOGICKY USTAV AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE (VVI)
Czechia
EU contribution
€ 201 600
Address
Videnska 1083
142 20 Praha 4
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jan Kopecky (Dr.)
EVOLVA BIOTECH A/S
Denmark
EU contribution
€ 367 184
Address
Lerso Parkalle 42-44
2100 Copenhagen Ø
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Martin Pedersen (Mr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 493 732,56
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Hélène Faradji (Dr.)
TECHNISCHE UNIVERSITAET GRAZ
Austria
EU contribution
€ 245 638
Address
Rechbauerstrasse 12
8010 Graz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marcel Scheideler (Dr.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

Participation ended

United Kingdom
EU contribution
€ 14 682,62
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tatjana Palalic (Ms.)
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 378 527
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wouter Van Marken Lichtenbelt (Dr.)
Maastricht Instruments
Netherlands
EU contribution
€ 83 517
Address
Universiteitssingel 50
6229 ER Maastricht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ralf Henskens (Mr.)
MILTENYI BIOTEC GMBH
Germany
EU contribution
€ 386 800
Address
Friedrich Ebert Strasse 68
51429 Bergish Gladbach
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Sabrina Schmitz (Ms.)
STOCKHOLMS UNIVERSITET
Sweden
EU contribution
€ 424 743
Address
Universitetsvagen 10
10691 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Barbara Cannon (Prof.)
TECHNISCHE UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 197 570
Address
Arcisstrasse 21
80333 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ulrike Ronchetti (Ms.)
UNIVERSITA POLITECNICA DELLE MARCHE
Italy
EU contribution
€ 197 760
Address
Piazza Roma 22
60121 Ancona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Saverio Cinti (Prof.)
UNIVERSITAT DE LES ILLES BALEARS
Spain
EU contribution
€ 211 260
Address
Carretera De Valldemossa Km 7.5
07122 Palma De Mallorca
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Xavier Garcias Amengual (Dr.)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 712 480
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ivan Kristoffersen (Mr.)
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 206 400
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Francoise Rohner-Jeanrenaud (Prof.)
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 210 371
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ellen Rydberg (Dr.)
TURUN YLIOPISTO
Finland
EU contribution
€ 349 600
Address
Yliopistonmaki
20014 Turku
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kirsi Anneli Virtanen (Dr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 178 005,44
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Muriel Bouas (Ms.)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 297 600
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christian Wolfrum (Prof.)
UNIVERSITE DE LAUSANNE
Switzerland
EU contribution
€ 91 200
Address
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nicolas Niederländer (Dr.)
THE UNIVERSITY OF WARWICK
United Kingdom
EU contribution
€ 185 145,38
Address
Kirby Corner Road - University House
CV4 8UW Coventry
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Trevor Brown