Objective We want to further develop our tools and technologies for high-throughput research, with the final goals being (I.) the particle-based combinatorial synthesis of 1 Mio different peptides on a glass slide for chemical costs of ~50€ (KIT, CBL, MS, TUV), and (II.) the labelling-free parallel readout of binding affinities by a variant reflectometric interference spectroscopy method for ~10.000 peptide spots per cm(+2) when staining the array with an unlabeled protein (BIA, KIT). These tools provide the basis (III.) for a standardized, fast, and reliable high-throughput procedure that we want to develop in order to find high-affinity peptide binders against any pharmaceutically interesting target protein. Such a procedure might have an important impact in medicine and in the biotechnology industry. In order to achieve this goal, we will use display techniques that in combination with high-throughput sequencing typically will identify ~100.000 putative peptide binders per target protein (ISO). These will be synthesized in array format to validate binding to the target protein by an independent method (PPP, DKFZ). Next, based on binders from initial screens, many variant peptides are synthesized in high-density array format for iterative screens (PPP, DKFZ, KIT), whereby massive parallel labelling-free detection of binders pinpoints higher-affinity binders (BIA). In order to validate our novel high-throughput procedure, (IV.) we want to find high-affinity peptide binders against relevant target proteins (delivered by APO and OXF), and test these binders in biological assays (OXF, APO). Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsengineering and technologymaterials engineeringnatural sciencesphysical sciencesopticsspectroscopy Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2011.1.1-1 - SME-targeted research for developing tools and technologies for high-throughput research Call for proposal FP7-HEALTH-2011-two-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator KARLSRUHER INSTITUT FUER TECHNOLOGIE Address Kaiserstrasse 12 76131 Karlsruhe Germany See on map Region Baden-Württemberg Karlsruhe Karlsruhe, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Natascha Wallburg (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all ISOGENICA LTD United Kingdom EU contribution € 700 500,00 Address The mansion, chesterford research park CB10 1XL Little chesterford saffron walden See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Chris Ullman (Dr.) Links Contact the organisation Opens in new window Other funding No data Center for Advanced Bioanalysis GmbH Austria EU contribution € 549 000,00 Address Scharitzerstrasse 6-8 4020 Linz See on map Activity type Research Organisations Administrative Contact Alois Sonnleitner (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data PEPperPRINT GmbH Germany EU contribution € 459 000,00 Address Schlossweg 9 69168 Wiesloch See on map Region Baden-Württemberg Karlsruhe Rhein-Neckar-Kreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Volker Stadler (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data BIAMETRICS GMBH Germany EU contribution € 471 000,00 Address Auf der morgenstelle 18 72076 Tubingen See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Guenther Proll (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 499 980,00 Address Wellington square university offices OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Stephen Conway (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data APOGENIX GMBH Germany EU contribution € 400 000,00 Address Im neuenheimer feld 584 69120 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jürgen Gamer (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG Germany EU contribution € 130 000,00 Address Im neuenheimer feld 280 69120 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Administrative Contact Bettina Crispin (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data MICROSYSTEMS LTD Bulgaria EU contribution € 100 000,00 Address Chaika 15 d 21 9010 Varna See on map Region Северна и Югоизточна България Североизточен Варна Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Nikolay Nikolov (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data TECHNICAL UNIVERSITY OF VARNA Bulgaria EU contribution € 70 200,00 Address Ul studentska 1 9010 Varna See on map Region Северна и Югоизточна България Североизточен Варна Activity type Higher or Secondary Education Establishments Administrative Contact Jordan Kolev (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
