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Tissue in Host Engineering Guided Regeneration of Arterial Intimal Layer

Objective

"The concept of THE GRAIL project is the creation of an in vivo, in situ structured bioactive, selectively porous, bioresorbable scaffold that locally regenerates intima growth after endovascular treatment of the obstructed arteries in patients with atherosclerosis. Arterial obstruction due to arteriosclerosis is the cause of a wide spectrum of diseases, disabilities and death, because of induced ischemia in feed arteries of the diseased organs. These organs include the brain (ischemic stroke), the heart , the kidneys, the gastrointestinal tract, the lower limbs (leading to amputations, especially in diabetic patients). The purpose of the in vivo tissue engineered (TE) blood vessel is to offer an alternative treatment for patients affected with this disease: to substitute the actual mechanical, acute oriented “rechanneling” or “by passing” of obstructed arteries with a regenerative, physiological, disease solving and long term oriented, approach in the therapy of ischemic cardiovascular disease, compatible with today minimal invasive surgical techniques. This is an unexplored area of approaches of therapy for arterial obstruction by TE technology: the substitution of the diseased arterial intima (atherosclerotic plaque removed) with an absorbable bioactive scaffold, called the synthesized intimal layer (SIL), to be repopulated by resident and circulating patient resident and stem cells. SIL does not intend to stent the artery; conversely it aims to replace the diseased and stiffened area with a soft and compliant intelligent scaffold that becomes reabsorbed once its task is completed , leaving a physiologically responsive regenerated tissue.
The project aims to merge the single laboratories ongoing work, coordinate it and finalizing it to bring it through the whole pre clinical process, including the whole regulatory work, the GLP animal pre clinical implants and the design and production of “TE device” deployment technology."

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Coordinator

EXPLORA SRL
Address
Via Giacomo Peroni 386
00131 Roma
Italy
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 1 436 920
Administrative Contact
Davide De Lucrezia (Dr.)

Participants (8)

TECHNICAL PROTEINS NANOBIOTECHNOLOGY SL
Spain
EU contribution
€ 229 940
Address
Paseo De Belen 11
47011 Valladolid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Alessandra Girotti (Dr.)
DONAWA LIFESCIENCE CONSULTING SRL
Italy
EU contribution
€ 275 000
Address
Piazza Albania 10
00153 Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Maria Elena Donawa (Dr.)
"CONIC VASCULAR TECHNOLOGY, S.A."
Switzerland
EU contribution
€ 596 300
Address
"Via G. Curti, 5"
6901 Lugano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nella Reina (Ms.)
UNIVERSIDAD DE VALLADOLID
Spain
EU contribution
€ 787 800
Address
Plaza Santa Cruz 8 Palacio De Santa Cruz
47002 Valladolid
Activity type
Higher or Secondary Education Establishments
Administrative Contact
José Carlos Rodriguez Cabello (Prof.)
THE UNIVERSITY OF LIVERPOOL
United Kingdom
EU contribution
€ 885 600
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pam Neagle (Ms.)
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Spain
EU contribution
€ 681 120
Address
Carrer Baldiri Reixac Planta 2A 10-12
08028 Barcelona
Activity type
Research Organisations
Administrative Contact
Planell Josep A. (Prof.)
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Italy
EU contribution
€ 675 440
Address
Corso Umberto I, 40
80138 Napoli
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paolo Netti (Prof.)
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 430 318
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pieter J.A. De Koning (Dr.)