Objective "The concept of THE GRAIL project is the creation of an in vivo, in situ structured bioactive, selectively porous, bioresorbable scaffold that locally regenerates intima growth after endovascular treatment of the obstructed arteries in patients with atherosclerosis. Arterial obstruction due to arteriosclerosis is the cause of a wide spectrum of diseases, disabilities and death, because of induced ischemia in feed arteries of the diseased organs. These organs include the brain (ischemic stroke), the heart , the kidneys, the gastrointestinal tract, the lower limbs (leading to amputations, especially in diabetic patients). The purpose of the in vivo tissue engineered (TE) blood vessel is to offer an alternative treatment for patients affected with this disease: to substitute the actual mechanical, acute oriented “rechanneling” or “by passing” of obstructed arteries with a regenerative, physiological, disease solving and long term oriented, approach in the therapy of ischemic cardiovascular disease, compatible with today minimal invasive surgical techniques. This is an unexplored area of approaches of therapy for arterial obstruction by TE technology: the substitution of the diseased arterial intima (atherosclerotic plaque removed) with an absorbable bioactive scaffold, called the synthesized intimal layer (SIL), to be repopulated by resident and circulating patient resident and stem cells. SIL does not intend to stent the artery; conversely it aims to replace the diseased and stiffened area with a soft and compliant intelligent scaffold that becomes reabsorbed once its task is completed , leaving a physiologically responsive regenerated tissue.The project aims to merge the single laboratories ongoing work, coordinate it and finalizing it to bring it through the whole pre clinical process, including the whole regulatory work, the GLP animal pre clinical implants and the design and production of “TE device” deployment technology." Fields of science medical and health sciencesclinical medicinecardiologycardiovascular diseasesarteriosclerosismedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesbasic medicineneurologystrokemedical and health sciencesmedical biotechnologyimplants Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2011.1.4-2 - Tools, technologies and devices for application in regenerative medicine Call for proposal FP7-HEALTH-2011-two-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator EXPLORA SRL Address Via giacomo peroni 386 00131 Roma Italy See on map Region Centro (IT) Lazio Roma Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Davide De Lucrezia (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all TECHNICAL PROTEINS NANOBIOTECHNOLOGY SL Spain EU contribution € 229 940,00 Address Paseo de belen 11 47011 Valladolid See on map Region Centro (ES) Castilla y León Valladolid Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Alessandra Girotti (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data DONAWA LIFESCIENCE CONSULTING SRL Italy EU contribution € 275 000,00 Address Piazza albania 10 00153 Roma See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Maria Elena Donawa (Dr.) Links Contact the organisation Opens in new window Other funding No data "CONIC VASCULAR TECHNOLOGY, S.A." Switzerland EU contribution € 596 300,00 Address "via g. curti, 5" 6901 Lugano See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Nella Reina (Ms.) Links Contact the organisation Opens in new window Other funding No data UNIVERSIDAD DE VALLADOLID Spain EU contribution € 787 800,00 Address Plaza santa cruz 8 palacio de santa cruz 47002 Valladolid See on map Region Centro (ES) Castilla y León Valladolid Activity type Higher or Secondary Education Establishments Administrative Contact José Carlos Rodriguez Cabello (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data THE UNIVERSITY OF LIVERPOOL United Kingdom EU contribution € 885 600,00 Address Brownlow hill 765 foundation building L69 7ZX Liverpool See on map Region North West (England) Merseyside Liverpool Activity type Higher or Secondary Education Establishments Administrative Contact Pam Neagle (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA Spain EU contribution € 681 120,00 Address Carrer baldiri reixac planta 2a 10-12 08028 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Administrative Contact Planell Josep A. (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II Italy EU contribution € 675 440,00 Address Corso umberto i, 40 80138 Napoli See on map Region Sud Campania Napoli Activity type Higher or Secondary Education Establishments Administrative Contact Paolo Netti (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITAIR MEDISCH CENTRUM UTRECHT Netherlands EU contribution € 430 318,00 Address Heidelberglaan 100 3584 CX Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Administrative Contact Pieter J.A. De Koning (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
