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Tissue in Host Engineering Guided Regeneration of Arterial Intimal Layer

Obiettivo

"The concept of THE GRAIL project is the creation of an in vivo, in situ structured bioactive, selectively porous, bioresorbable scaffold that locally regenerates intima growth after endovascular treatment of the obstructed arteries in patients with atherosclerosis. Arterial obstruction due to arteriosclerosis is the cause of a wide spectrum of diseases, disabilities and death, because of induced ischemia in feed arteries of the diseased organs. These organs include the brain (ischemic stroke), the heart , the kidneys, the gastrointestinal tract, the lower limbs (leading to amputations, especially in diabetic patients). The purpose of the in vivo tissue engineered (TE) blood vessel is to offer an alternative treatment for patients affected with this disease: to substitute the actual mechanical, acute oriented “rechanneling” or “by passing” of obstructed arteries with a regenerative, physiological, disease solving and long term oriented, approach in the therapy of ischemic cardiovascular disease, compatible with today minimal invasive surgical techniques. This is an unexplored area of approaches of therapy for arterial obstruction by TE technology: the substitution of the diseased arterial intima (atherosclerotic plaque removed) with an absorbable bioactive scaffold, called the synthesized intimal layer (SIL), to be repopulated by resident and circulating patient resident and stem cells. SIL does not intend to stent the artery; conversely it aims to replace the diseased and stiffened area with a soft and compliant intelligent scaffold that becomes reabsorbed once its task is completed , leaving a physiologically responsive regenerated tissue.
The project aims to merge the single laboratories ongoing work, coordinate it and finalizing it to bring it through the whole pre clinical process, including the whole regulatory work, the GLP animal pre clinical implants and the design and production of “TE device” deployment technology."

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Coordinatore

EXPLORA SRL
Indirizzo
Via Giacomo Peroni 386
00131 Roma
Italia
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contributo UE
€ 1 436 920
Contatto amministrativo
Davide De Lucrezia (Dr.)

Partecipanti (8)

TECHNICAL PROTEINS NANOBIOTECHNOLOGY SL
Spagna
Contributo UE
€ 229 940
Indirizzo
Paseo De Belen 11
47011 Valladolid
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Alessandra Girotti (Dr.)
DONAWA LIFESCIENCE CONSULTING SRL
Italia
Contributo UE
€ 275 000
Indirizzo
Piazza Albania 10
00153 Roma
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Maria Elena Donawa (Dr.)
"CONIC VASCULAR TECHNOLOGY, S.A."
Svizzera
Contributo UE
€ 596 300
Indirizzo
"Via G. Curti, 5"
6901 Lugano
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Nella Reina (Ms.)
UNIVERSIDAD DE VALLADOLID
Spagna
Contributo UE
€ 787 800
Indirizzo
Plaza Santa Cruz 8 Palacio De Santa Cruz
47002 Valladolid
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
José Carlos Rodriguez Cabello (Prof.)
THE UNIVERSITY OF LIVERPOOL
United Kingdom
Contributo UE
€ 885 600
Indirizzo
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Pam Neagle (Ms.)
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Spagna
Contributo UE
€ 681 120
Indirizzo
Carrer Baldiri Reixac Planta 2A 10-12
08028 Barcelona
Tipo di attività
Research Organisations
Contatto amministrativo
Planell Josep A. (Prof.)
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Italia
Contributo UE
€ 675 440
Indirizzo
Corso Umberto I, 40
80138 Napoli
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Paolo Netti (Prof.)
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Paesi Bassi
Contributo UE
€ 430 318
Indirizzo
Heidelberglaan 100
3584 CX Utrecht
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Pieter J.A. De Koning (Dr.)