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Tissue in Host Engineering Guided Regeneration of Arterial Intimal Layer

Ziel

"The concept of THE GRAIL project is the creation of an in vivo, in situ structured bioactive, selectively porous, bioresorbable scaffold that locally regenerates intima growth after endovascular treatment of the obstructed arteries in patients with atherosclerosis. Arterial obstruction due to arteriosclerosis is the cause of a wide spectrum of diseases, disabilities and death, because of induced ischemia in feed arteries of the diseased organs. These organs include the brain (ischemic stroke), the heart , the kidneys, the gastrointestinal tract, the lower limbs (leading to amputations, especially in diabetic patients). The purpose of the in vivo tissue engineered (TE) blood vessel is to offer an alternative treatment for patients affected with this disease: to substitute the actual mechanical, acute oriented “rechanneling” or “by passing” of obstructed arteries with a regenerative, physiological, disease solving and long term oriented, approach in the therapy of ischemic cardiovascular disease, compatible with today minimal invasive surgical techniques. This is an unexplored area of approaches of therapy for arterial obstruction by TE technology: the substitution of the diseased arterial intima (atherosclerotic plaque removed) with an absorbable bioactive scaffold, called the synthesized intimal layer (SIL), to be repopulated by resident and circulating patient resident and stem cells. SIL does not intend to stent the artery; conversely it aims to replace the diseased and stiffened area with a soft and compliant intelligent scaffold that becomes reabsorbed once its task is completed , leaving a physiologically responsive regenerated tissue.
The project aims to merge the single laboratories ongoing work, coordinate it and finalizing it to bring it through the whole pre clinical process, including the whole regulatory work, the GLP animal pre clinical implants and the design and production of “TE device” deployment technology."

Aufforderung zur Vorschlagseinreichung

FP7-HEALTH-2011-two-stage
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

CP-FP - Small or medium-scale focused research project

Koordinator

EXPLORA SRL
Adresse
Via Giacomo Peroni 386
00131 Roma
Italien
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU-Beitrag
€ 1 436 920
Kontakt Verwaltung
Davide De Lucrezia (Dr.)

Beteiligte (8)

TECHNICAL PROTEINS NANOBIOTECHNOLOGY SL
Spanien
EU-Beitrag
€ 229 940
Adresse
Paseo De Belen 11
47011 Valladolid
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Alessandra Girotti (Dr.)
DONAWA LIFESCIENCE CONSULTING SRL
Italien
EU-Beitrag
€ 275 000
Adresse
Piazza Albania 10
00153 Roma
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Maria Elena Donawa (Dr.)
"CONIC VASCULAR TECHNOLOGY, S.A."
Schweiz
EU-Beitrag
€ 596 300
Adresse
"Via G. Curti, 5"
6901 Lugano
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Nella Reina (Ms.)
UNIVERSIDAD DE VALLADOLID
Spanien
EU-Beitrag
€ 787 800
Adresse
Plaza Santa Cruz 8 Palacio De Santa Cruz
47002 Valladolid
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
José Carlos Rodriguez Cabello (Prof.)
THE UNIVERSITY OF LIVERPOOL
United Kingdom
EU-Beitrag
€ 885 600
Adresse
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Pam Neagle (Ms.)
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Spanien
EU-Beitrag
€ 681 120
Adresse
Carrer Baldiri Reixac Planta 2A 10-12
08028 Barcelona
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Planell Josep A. (Prof.)
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Italien
EU-Beitrag
€ 675 440
Adresse
Corso Umberto I, 40
80138 Napoli
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Paolo Netti (Prof.)
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Niederlande
EU-Beitrag
€ 430 318
Adresse
Heidelberglaan 100
3584 CX Utrecht
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Pieter J.A. De Koning (Dr.)