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Tissue in Host Engineering Guided Regeneration of Arterial Intimal Layer

Cel

"The concept of THE GRAIL project is the creation of an in vivo, in situ structured bioactive, selectively porous, bioresorbable scaffold that locally regenerates intima growth after endovascular treatment of the obstructed arteries in patients with atherosclerosis. Arterial obstruction due to arteriosclerosis is the cause of a wide spectrum of diseases, disabilities and death, because of induced ischemia in feed arteries of the diseased organs. These organs include the brain (ischemic stroke), the heart , the kidneys, the gastrointestinal tract, the lower limbs (leading to amputations, especially in diabetic patients). The purpose of the in vivo tissue engineered (TE) blood vessel is to offer an alternative treatment for patients affected with this disease: to substitute the actual mechanical, acute oriented “rechanneling” or “by passing” of obstructed arteries with a regenerative, physiological, disease solving and long term oriented, approach in the therapy of ischemic cardiovascular disease, compatible with today minimal invasive surgical techniques. This is an unexplored area of approaches of therapy for arterial obstruction by TE technology: the substitution of the diseased arterial intima (atherosclerotic plaque removed) with an absorbable bioactive scaffold, called the synthesized intimal layer (SIL), to be repopulated by resident and circulating patient resident and stem cells. SIL does not intend to stent the artery; conversely it aims to replace the diseased and stiffened area with a soft and compliant intelligent scaffold that becomes reabsorbed once its task is completed , leaving a physiologically responsive regenerated tissue.
The project aims to merge the single laboratories ongoing work, coordinate it and finalizing it to bring it through the whole pre clinical process, including the whole regulatory work, the GLP animal pre clinical implants and the design and production of “TE device” deployment technology."

Zaproszenie do składania wniosków

FP7-HEALTH-2011-two-stage
Zobacz inne projekty w ramach tego zaproszenia

Koordynator

EXPLORA SRL
Adres
Via Giacomo Peroni 386
00131 Roma
Włochy
Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Wkład UE
€ 1 436 920
Kontakt administracyjny
Davide De Lucrezia (Dr.)

Uczestnicy (8)

TECHNICAL PROTEINS NANOBIOTECHNOLOGY SL
Hiszpania
Wkład UE
€ 229 940
Adres
Paseo De Belen 11
47011 Valladolid
Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Alessandra Girotti (Dr.)
DONAWA LIFESCIENCE CONSULTING SRL
Włochy
Wkład UE
€ 275 000
Adres
Piazza Albania 10
00153 Roma
Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Maria Elena Donawa (Dr.)
"CONIC VASCULAR TECHNOLOGY, S.A."
Szwajcaria
Wkład UE
€ 596 300
Adres
"Via G. Curti, 5"
6901 Lugano
Rodzaj działalności
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Nella Reina (Ms.)
UNIVERSIDAD DE VALLADOLID
Hiszpania
Wkład UE
€ 787 800
Adres
Plaza Santa Cruz 8 Palacio De Santa Cruz
47002 Valladolid
Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
José Carlos Rodriguez Cabello (Prof.)
THE UNIVERSITY OF LIVERPOOL
United Kingdom
Wkład UE
€ 885 600
Adres
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Pam Neagle (Ms.)
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Hiszpania
Wkład UE
€ 681 120
Adres
Carrer Baldiri Reixac Planta 2A 10-12
08028 Barcelona
Rodzaj działalności
Research Organisations
Kontakt administracyjny
Planell Josep A. (Prof.)
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Włochy
Wkład UE
€ 675 440
Adres
Corso Umberto I, 40
80138 Napoli
Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Paolo Netti (Prof.)
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Niderlandy
Wkład UE
€ 430 318
Adres
Heidelberglaan 100
3584 CX Utrecht
Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Pieter J.A. De Koning (Dr.)