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From Flat to Chiral: A unified approach to converting achiral aromatic compounds to optically active valuable building blocks

Objective

"The stereoselective preparation of enantioenriched organic compounds of high structural complexity and synthetic value, in an economically viable and expeditious manner, is one of the most important goals in contemporary Organic Synthesis. In this proposal, I present a unified and conceptually novel approach for the conversion of flat, aromatic heterocycles into highly valuable compounds for a variety of applications. This approach hinges upon a synergistic combination of the dramatic power of organic photochemical transformations combined with the exceedingly high selectivity and atom-economy of efficient catalytic processes. Indeed, the use of probably the cheapest reagent (light) combined with a catalytic transformation ensures near perfect atom-economy in this journey from flat and inexpensive substructures to chiral added-value products. Conceptually, the photochemical operation is envisaged as a energy-loading step whereas the catalytic transformation functions as an energy-release where asymmetric information is inscribed into the products.
The chemistry proposed herein will open up new vistas in enantioselective synthesis. Furthermore, groundbreaking and unprecedented methodology in the field of catalytic allylic alkylation is proposed that significantly expands (and goes beyond) the currently accepted “dogmas” for these textbook reactions. These include (but are not limited to) systematic violations of well-established rules “by design”, new contexts for application, new activation modes and innovative leaving groups. Finally, the comprehensive body of synthetic technology presented will be applied to pressing target-oriented problems in Organic Synthesis. It shall result in a landmark, highly efficient total synthesis of Tamiflu, as well as in application to an environmentally important target (Fomannosin), allowing the easy production of analogues for biological testing."

Field of science

  • /natural sciences/chemical sciences/organic chemistry/aromatic compounds

Call for proposal

ERC-2011-StG_20101014
See other projects for this call

Funding Scheme

ERC-SG - ERC Starting Grant

Host institution

UNIVERSITAT WIEN
Address
Universitatsring 1
1010 Wien
Austria
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 235 000
Principal investigator
Nuno Xavier Dias Maulide (Dr.)
Administrative Contact
Helmut Schaschl (Dr.)

Beneficiaries (2)

UNIVERSITAT WIEN
Austria
EU contribution
€ 1 235 000
Address
Universitatsring 1
1010 Wien
Activity type
Higher or Secondary Education Establishments
Principal investigator
Nuno Xavier Dias Maulide (Dr.)
Administrative Contact
Helmut Schaschl (Dr.)
MAX PLANCK INSTITUT FUER KOHLENFORSCHUNG

Participation ended

Germany
EU contribution
€ 252 000
Address
Kaiser Wilhelm Platz 1
45470 Muelheim An Der Ruhr
Activity type
Research Organisations
Administrative Contact
Salome Marenya (Ms.)