Skip to main content
European Commission logo
italiano italiano
CORDIS - Risultati della ricerca dell’UE
CORDIS
CORDIS Web 30th anniversary CORDIS Web 30th anniversary
Contenuto archiviato il 2024-05-28

From Flat to Chiral: A unified approach to converting achiral aromatic compounds to optically active valuable building blocks

Obiettivo

The stereoselective preparation of enantioenriched organic compounds of high structural complexity and synthetic value, in an economically viable and expeditious manner, is one of the most important goals in contemporary Organic Synthesis. In this proposal, I present a unified and conceptually novel approach for the conversion of flat, aromatic heterocycles into highly valuable compounds for a variety of applications. This approach hinges upon a synergistic combination of the dramatic power of organic photochemical transformations combined with the exceedingly high selectivity and atom-economy of efficient catalytic processes. Indeed, the use of probably the cheapest reagent (light) combined with a catalytic transformation ensures near perfect atom-economy in this journey from flat and inexpensive substructures to chiral added-value products. Conceptually, the photochemical operation is envisaged as a energy-loading step whereas the catalytic transformation functions as an energy-release where asymmetric information is inscribed into the products.
The chemistry proposed herein will open up new vistas in enantioselective synthesis. Furthermore, groundbreaking and unprecedented methodology in the field of catalytic allylic alkylation is proposed that significantly expands (and goes beyond) the currently accepted “dogmas” for these textbook reactions. These include (but are not limited to) systematic violations of well-established rules “by design”, new contexts for application, new activation modes and innovative leaving groups. Finally, the comprehensive body of synthetic technology presented will be applied to pressing target-oriented problems in Organic Synthesis. It shall result in a landmark, highly efficient total synthesis of Tamiflu, as well as in application to an environmentally important target (Fomannosin), allowing the easy production of analogues for biological testing.

Invito a presentare proposte

ERC-2011-StG_20101014
Vedi altri progetti per questo bando

Meccanismo di finanziamento

ERC-SG - ERC Starting Grant

Istituzione ospitante

UNIVERSITAT WIEN
Contributo UE
€ 1 235 000,00
Indirizzo
UNIVERSITATSRING 1
1010 Wien
Austria

Mostra sulla mappa

Regione
Ostösterreich Wien Wien
Tipo di attività
Higher or Secondary Education Establishments
Ricercatore principale
Nuno Xavier Dias Maulide (Dr.)
Contatto amministrativo
Helmut Schaschl (Dr.)
Collegamenti
Costo totale
Nessun dato

Beneficiari (2)