Objectif Nuclear pore complexes (NPCs) form macromolecular assemblies in the nuclear envelope and mediate bidirectional cargo movement between the nucleus and cytoplasm. Recent evidence suggests that NPCs are not merely transport channels but act as gene regulators. Studies in yeast demonstrate that inducible genes can reposition from the nuclear interior to the nuclear periphery upon activation. At the periphery activated genes engage in physical contacts with nuclear pores. Targeting and tethering of genes to nuclear pores involves multifunctional adaptor complexes, which are thought to couple chromatin modification, transcription and mRNA export. Knowledge of the structure, dynamics and evolution of these adaptor complexes is key to understanding how NPCs control nuclear gene positioning and gene expression. I propose to systematically dissect the architecture and function of NPC-associated adaptor complexes. Our studies will be a unique combination of biochemical and structural approaches in three different model organisms. I anticipate, that this line of research will create a powerful basis to address a number of key questions in the field. Champ scientifique natural sciencesbiological sciencesgeneticsgenomes Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-SG-LS1 - ERC Starting Grant - Molecular and Structural Biology and Biochemistry Appel à propositions ERC-2011-StG_20101109 Voir d’autres projets de cet appel Régime de financement ERC-SG - ERC Starting Grant Institution d’accueil MEDIZINISCHE UNIVERSITAET WIEN Contribution de l’UE € 1 481 556,00 Adresse SPITALGASSE 23 1090 Wien Autriche Voir sur la carte Région Ostösterreich Wien Wien Type d’activité Higher or Secondary Education Establishments Chercheur principal Alwin Köhler (Dr.) Contact administratif Alwin Köhler (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire MEDIZINISCHE UNIVERSITAET WIEN Autriche Contribution de l’UE € 1 481 556,00 Adresse SPITALGASSE 23 1090 Wien Voir sur la carte Région Ostösterreich Wien Wien Type d’activité Higher or Secondary Education Establishments Chercheur principal Alwin Köhler (Dr.) Contact administratif Alwin Köhler (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée