Objective Several studies have linked the use of insulins to the risk of cancer, and it is certainly plausible that as a growth factor, exposure to administered insulin could stimulate neoplastic growth. However, the meta-analyses of randomized clinical trials comparing different insulin analogues were too small to quantify the risks, especially the proportion of patients that were followed for more than 6 months. Hence, the European Medicines Agency has requested urgent research to determine the risks of cancer for users of insulin and insulin analogues, and investigate possible mechanisms of cancer promotion.CARING will obtain precise data on the incidence of cancer in diabetic patients and determine any link with use of various insulin and insulin analogues. The study will utilise high quality prescription databases and other national datasources, integrated at European level with advanced methods of harmonising data. The study will take into account potential confounders. The project aims to determine the influence of drug dose on risk, and through a risk model, identify predictors of cancer for insulin users. A review of published evidence combined with a study of tumour characteristics and gene expression in breast cancer tumour collections will aid understanding of potential mechanisms of cancer initiation and/or promotion by insulin.The project consortium involves some of the most experienced pharmacoepidemiology groups in Europe, and a leading cancer research institute. The consortium will liaise closely with the European Medicines Agency and other stakeholders throughout the study. Fields of science natural sciencescomputer and information sciencesdatabasesmedical and health sciencesclinical medicineoncologybreast cancer Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2011.4.2-2 - Adverse Drug Reaction Research Call for proposal FP7-HEALTH-2011-single-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator UNIVERSITEIT UTRECHT Address Heidelberglaan 8 3584 CS Utrecht Netherlands See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Administrative Contact M.L. De Bruin (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all AARHUS UNIVERSITETSHOSPITAL Denmark EU contribution € 432 208,00 Address Palle juul-jensens boulevard 99 8200 Aarhus See on map Region Danmark Midtjylland Østjylland Activity type Research Organisations Administrative Contact Peter Vestergaard (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data FOLKEHELSEINSTITUTTET Norway EU contribution € 329 396,00 Address Lovisenberggata 8 0456 Oslo See on map Region Norge Oslo og Viken Oslo Activity type Research Organisations Administrative Contact Aage Tverdal (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data KAROLINSKA INSTITUTET Sweden EU contribution € 434 360,00 Address Nobels vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Caroline Hamilton (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data TAMPEREEN YLIOPISTO Finland EU contribution € 130 040,00 Address Kalevantie 4 33014 Tampere See on map Activity type Higher or Secondary Education Establishments Administrative Contact Susanna Airila (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data HELSINGIN YLIOPISTO Finland EU contribution € 264 400,00 Address Yliopistonkatu 3 00014 Helsingin yliopisto See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Higher or Secondary Education Establishments Administrative Contact Sanna Leppämäki (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS Netherlands EU contribution € 457 500,00 Address Plesmanlaan 121 1066 CX Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Research Organisations Administrative Contact Henri Van Luenen (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
