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Developmental neurotoxicity assessment of mixtures in children

Objective

Various recent epidemiological studies have indicated that exposure to low doses of environmental biologically active contaminants during human development can alter gene expression and have deleterious effects on cognitive development in childhood. The DENAMIC project is ultimately focused on reducing such effects of environmental contamination on learning and developmental disorders in children. It aims to study and evaluate environment-health relationships in children. Key elements are: development of sophisticated tools and methods for early warning and screening of compounds for neurotoxicity, to study mechanisms of disease development and the role of individual susceptibility, to improve assessment of exposures and effects, focus on combined exposures to environmental agents that can interact to enhance adverse effects and reduction of health inequalities of children through Europe. One of the main aims of DENAMIC is to develop tools and methods for neurotoxic effects of mixtures of environmental pollutants at low levels, possibly resulting in (subclinical) effects on learning (cognitive skills) and developmental disorders in children (e.g ADHD, autism spectrum disorders and anxiety disorders). A broad suite of contaminants will be included in the studies, with options to bring in new chemicals in case evidence comes up during the project. With 14 partners from ten different countries DENAMIC has a true international character. It is a comprehensive, multi-disciplinary project. Six SME’s will play a key role in the development of biotechnological screening tools. The most modern techniques in the fields of genomics, proteomics, metabolomics and transcriptomics will be applied. Dissemination will ensure the project results to arrive at policymakers' desks, and will also illustrate the subject for a scientific audience and the public. The very large network of the consortium ensures dissemination to European industries, and every other interested stakeholder.

Field of science

  • /medical and health sciences/clinical medicine/psychiatry/anxiety disorders
  • /social sciences/other social sciences/social sciences interdisciplinary/sustainable development

Call for proposal

FP7-ENV-2011
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

STICHTING VU
Address
De Boelelaan 1105
1081 HV Amsterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 559 968,40
Administrative Contact
Kops Yvonne (Dr.)

Participants (15)

UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 1 070 228,50
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Monique Van Der Hoek (Mrs.)
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 747 180,80
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ingvar Brandt (Prof.)
FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPEFELIPE
Spain
EU contribution
€ 649 130
Address
Calle Eduardo Primo Yufera 3
46012 Valencia
Activity type
Research Organisations
Administrative Contact
Oscar Sanchez (Mr.)
SLOVENSKA ZDRAVOTNICKA UNIVERZITA V BRATISLAVE
Slovakia
EU contribution
€ 65 155,25
Address
Limbova 12
83303 Bratislava
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lubica Palkovicova (Dr.)
CALLISTO PRODUCTIONS LTD
United Kingdom
EU contribution
€ 167 000
Address
Carolines Crescent
AB41 8BN Ellon, Abberdeenshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Tom Mcinnes (Mr.)
CENTRO SUPERIOR DE INVESTIGACION EN SALUD PUBLICA
Spain
Address
Avenida De Catalunya 21
46020 Valencia
Activity type
Research Organisations
Administrative Contact
Juana M. Ferrús (Ms.)
FOLKEHELSEINSTITUTTET
Norway
EU contribution
€ 438 200
Address
Lovisenberggata 8
0456 Oslo
Activity type
Research Organisations
Administrative Contact
Frederik Froen (Dr.)
Instituto de Medicina Genómica
Spain
EU contribution
€ 530 960
Address
Catedratico Agustin Escardino 9
E46980 Paterna
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Carlos Gutierrez-Muñoz (Mr.)
VIEW POINT
France
EU contribution
€ 235 834
Address
Technoparc Saone Valle
01390 Civrieux
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Didier Neuzeret (Mr.)
Proteome Sciences R&D GmbH & Co. KG
Germany
EU contribution
€ 530 033
Address
Altenhöferallee 3
60438 Frankfurt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Juliana Watterston
INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU ELECTROCHIMIE SI MATERIE CONDENSATA - INCEMC TIMISOARA
Romania
EU contribution
€ 52 500
Address
Aurel Paunescu Podeanu 144
300569 Timisoara
Activity type
Research Organisations
Administrative Contact
Mirela Ioana Iorga (Ms.)
GEN-INFO ZA USLUGE D.O.O.
Croatia
EU contribution
€ 59 856,30
Address
Ruzmarinka 17
10000 Zagreb
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Dalibora Rako (Ms.)
Masarykova univerzita
Czechia
EU contribution
€ 424 344,75
Address
Zerotinovo Namesti 9
60177 Brno Stred
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Roman Hladik (Mr.)
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG
Netherlands
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Westerlaken Inge (Ms.)
FUNDACION PARA EL FOMENTO DE LA INVESTIGACION SANITARIA Y BIOMEDICA DE LA COMUNITAT VALENCIANA
Spain
EU contribution
€ 463 472,40
Address
Calle Micer Masco 31
46010 Valencia
Activity type
Research Organisations
Administrative Contact
Juana M. Ferrús (Ms.)