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Developmental neurotoxicity assessment of mixtures in children

Obiettivo

Various recent epidemiological studies have indicated that exposure to low doses of environmental biologically active contaminants during human development can alter gene expression and have deleterious effects on cognitive development in childhood. The DENAMIC project is ultimately focused on reducing such effects of environmental contamination on learning and developmental disorders in children. It aims to study and evaluate environment-health relationships in children. Key elements are: development of sophisticated tools and methods for early warning and screening of compounds for neurotoxicity, to study mechanisms of disease development and the role of individual susceptibility, to improve assessment of exposures and effects, focus on combined exposures to environmental agents that can interact to enhance adverse effects and reduction of health inequalities of children through Europe. One of the main aims of DENAMIC is to develop tools and methods for neurotoxic effects of mixtures of environmental pollutants at low levels, possibly resulting in (subclinical) effects on learning (cognitive skills) and developmental disorders in children (e.g ADHD, autism spectrum disorders and anxiety disorders). A broad suite of contaminants will be included in the studies, with options to bring in new chemicals in case evidence comes up during the project. With 14 partners from ten different countries DENAMIC has a true international character. It is a comprehensive, multi-disciplinary project. Six SME’s will play a key role in the development of biotechnological screening tools. The most modern techniques in the fields of genomics, proteomics, metabolomics and transcriptomics will be applied. Dissemination will ensure the project results to arrive at policymakers' desks, and will also illustrate the subject for a scientific audience and the public. The very large network of the consortium ensures dissemination to European industries, and every other interested stakeholder.

Invito a presentare proposte

FP7-ENV-2011
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Meccanismo di finanziamento

CP-IP - Large-scale integrating project
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Coordinatore

STICHTING VU
Indirizzo
De boelelaan 1105
1081 HV Amsterdam
Paesi Bassi

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Regione
West-Nederland Noord-Holland Groot-Amsterdam
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Kops Yvonne (Dr.)
Collegamenti
Contributo UE
Nessun dato

Partecipanti (15)