Obiettivo
Various recent epidemiological studies have indicated that exposure to low doses of environmental biologically active contaminants during human development can alter gene expression and have deleterious effects on cognitive development in childhood. The DENAMIC project is ultimately focused on reducing such effects of environmental contamination on learning and developmental disorders in children. It aims to study and evaluate environment-health relationships in children. Key elements are: development of sophisticated tools and methods for early warning and screening of compounds for neurotoxicity, to study mechanisms of disease development and the role of individual susceptibility, to improve assessment of exposures and effects, focus on combined exposures to environmental agents that can interact to enhance adverse effects and reduction of health inequalities of children through Europe. One of the main aims of DENAMIC is to develop tools and methods for neurotoxic effects of mixtures of environmental pollutants at low levels, possibly resulting in (subclinical) effects on learning (cognitive skills) and developmental disorders in children (e.g ADHD, autism spectrum disorders and anxiety disorders). A broad suite of contaminants will be included in the studies, with options to bring in new chemicals in case evidence comes up during the project. With 14 partners from ten different countries DENAMIC has a true international character. It is a comprehensive, multi-disciplinary project. Six SME’s will play a key role in the development of biotechnological screening tools. The most modern techniques in the fields of genomics, proteomics, metabolomics and transcriptomics will be applied. Dissemination will ensure the project results to arrive at policymakers' desks, and will also illustrate the subject for a scientific audience and the public. The very large network of the consortium ensures dissemination to European industries, and every other interested stakeholder.
Campo scientifico
Programma(i)
Invito a presentare proposte
FP7-ENV-2011
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Meccanismo di finanziamento
CP-IP - Large-scale integrating projectCoordinatore
1081 HV Amsterdam
Paesi Bassi
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Partecipanti (15)
3584 CS Utrecht
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751 05 Uppsala
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46012 Valencia
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833 03 Bratislava
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AB41 8BN ELLON, ABBERDEENSHIRE
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46020 Valencia
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0456 Oslo
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46024 VALENCIA
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01390 Civrieux
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60438 Frankfurt
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300569 TIMISOARA
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10000 ZAGREB
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601 77 Brno
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1081 HV Amsterdam
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46010 Valencia
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