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Development of a Novel Treatment for Clostridium Difficile

Objective

"We wish to exploit the need for effective treatment for nosocomial diarrhoea especially that caused by Clostridium difficile

disease (CDD). Patients treated with broad spectrum antibiotics are at greatest risk of CDD diarrhoea and many of those

affected are hospitalised elderly patients with serious underlying illnesses. Antibiotics can cause disruption of the normal

intestinal flora, an important part of the immune system, leading to an overgrowth of CDD. Currently, some 2350 patients

suffering from chronic CDD in a number of countries have been treated by faecal bacteriotherapy (FB), using samples

collected from donors. Although this procedure is reported, in a number of small studies, to be around 90% effective, it is

hazardous, in that infection from the donor could be transmitted to the patient and it involves delivery of faecal samples into

the duodenum via a nasal probe.

We propose to treat CDD using a modified FB to restore the patient’s original intestinal flora (employing samples collected

from the patients themselves prior to their treatment) We will produce novel enteric-coated capsules, containing processed

freeze dried colonic flora that can be swallowed by a patient to restore their intestinal flora and immunise them against

further infection by CDD. RFID tags will be employed to associate capsules with the relevant patient and assist with sample

inventory.

3 SMEs in 3 EU states and 5 distinguished research providers along with 1 OTHER SME in the coordination role will collaborate to provide the necessary technology to the project. The coordinator has previously coordinated an EU proposal and acted as a participant in projects over several

Frameworks. The outcome will be a non-antibiotic medicament to treat and prevent CDD The consortium plan to patent the

IPR from the project, exploit and disseminate the technology worldwide and carry out animal and hospital clinical studies.

There are no gender issues related to the proposal but animal and human studies will require ethical approval."

Call for proposal

FP7-SME-2011
See other projects for this call

Funding Scheme

BSG-SME - Research for SMEs

Coordinator

PNO CONSULTANTS LIMITED
Address
Earl Road 1 The Courtyard
SK8 6GN Cheadle Hulme
United Kingdom
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 19 200
Administrative Contact
James Craven (Mr.)

Participants (8)

WILLIAM JOHN MARTIN
United Kingdom
EU contribution
€ 217 686
Address
Derbyshire Road 4 Ashburn House
M33 3EG Sale
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
William John Martin (Dr.)
SYONIC SRL
Romania
EU contribution
€ 125 514
Address
Strada Dr Grigore T Popa Et Iv Ap 6-8 Si Et Vi Ap 14 81
300291 Timisoara Timis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Andras Kuglis (Mr.)
"MEDICINA, INNOVAZIONE E RICERCA SRL"
Italy
EU contribution
€ 169 200
Address
Via Giacomo Peroni 400
00131 Rome
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Antonio Assenso (Dr.)
CROSS-CHECK SYSTEMS LTD
United Kingdom
Address
Weston Hall Road Greenbox
B60 4AL Bromsgrove
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Paul Mason (Mr.)
UNIVERSITY OF GLASGOW
United Kingdom
Address
University Avenue
G12 8QQ Glasgow
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gillian Douce (Dr.)
THE MANCHESTER METROPOLITAN UNIVERSITY
United Kingdom
Address
Oxford Road All Saints Building
M15 6BH Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maggy Taylor (Ms.)
BIOPHARMA TECHNOLOGY LTD
United Kingdom
Address
Winnall Valley Road 9
SO23 0LD Winchester
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Isobel Cook (Mrs.)
POLYCOM PREDELAVA PLASTICNIH MAS INORODJARSTVO SKOFJA LOKA DOO
Slovenia
Address
Poljane Nad Skofjo Loko 76
4223 Poljane Nad Skofjo Loko
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Damjan Rozman (Mr.)