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Exgenome Molecular Enzymes

Objective

"The main objective of the EXGENOMES project is to develop new and improved thermostable enzymes for use, as reagents, in large-scale DNA synthesis and/or that can act on unnatural components such as in LNA (Locked Nucleic Acids). The target source for the new enzymes is a range of self-replicating mobile genetic elements (phages, plasmids and transposons) from thermophilic bacteria. Increased understanding of self-replication in many mobile genetic elements, such as phi29, has now made the commercial development of new self-priming & strand-displacing polymerases and other enzymes, much more plausible. A number of candidate enzymes, such as a new transposon-coded Thermus DNA polymerase are at hand for this project in the thermophilic bacteria & phage genome bank at Matis.

Nucleic acids based technologies now underpin a large and fast-growing industry, including research, diagnostics and pharmaceutical production. Thermophilic enzymes have played a key role in this development, as polymerases (DNA and RNA), ligases, nucleases, reverse transcriptases, polynucleotide kinases, lysozymes and more, are of great importance in the research industry today. The partner SME´s are all active players in this area from bioprospecting (Prokazyme), laboratory distribution (A&A Biotechnologies), LNA manufacture & diagnostics (Exiqon) to DNA vaccine production (Touchlight Genetics).

Together with the highly competent RTD partners the consortium is well positioned to implement the project according to its goals. The successful development of new thermostable polymerases and other enzymes with the desired properties would have a substantial impact on strengthening the current market status of the SME partners, resulting in growth in income and employment."

Call for proposal

FP7-SME-2011
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Coordinator

PROKAZYME EHF
Address
Vinlandsleio 14
113 Reykjavik
Iceland

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jakob Kristjansson (Dr.)
EU contribution
€ 332 749

Participants (7)

A&A BIOTECHNOLOGY SC
Poland
EU contribution
€ 285 840
Address
Al Zwyciestwa 96/98
84 451 Gdynia

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Slawomir Dabrowski (Dr.)
TOUCHLIGHT GENETICS LIMITED
United Kingdom
EU contribution
€ 154 177
Address
Queen Anne Street 40
W1G 9EL London

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Neil Porter (Dr.)
EXIQON A/S
Denmark
EU contribution
€ 143 834
Address
Bygstubben 9
2950 Vedbaek

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Peter Mouritzen (Dr.)
MATIS OHF
Iceland
Address
Vinlandsleid 12
113 Reykjavik

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Activity type
Research Organisations
Administrative Contact
Gudmunur Hreggvidsson (Dr.)
UNIWERSYTET GDANSKI
Poland
Address
Ul. Bazynskiego 8
80309 Gdansk

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tadeusz Kaczorowski (Prof.)
MIEDZYNARODOWY INSTYTUT BIOLOGII MOLEKULARNEJ I KOMORKOWEJ
Poland
Address
Ul. Ksiecia Trojdena 4
02109 Warszawa

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Activity type
Research Organisations
Administrative Contact
Janusz Bujnicki (Prof.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
Address
South Kensington Campus Exhibition Road
SW7 2AZ London

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tatjana Palalic (Ms.)