Project description
Personal Health Systems (PHS)
d-LIVER applies scenario-driven development methodologies to address an unmet need for bio-artificial liver support via continuous detoxification as remote transient therapy at the Point-of-Need. The liver is a complex organ with various vital functions in synthesis, detoxification and regulation; its failure is life-threatening and the only curative treatment is transplantation. Whilst awaiting transplantation, or after liver resection, patients need to be supported with detoxification systems which, currently mainly based on filtration, do not support metabolic liver function. This can only be provided by living cells. Thus, development of ICT-enabled bio-artificial liver support systems with associated remote monitoring to assist in the treatment and management of liver patients in care settings extending from the hospital to the home is essential.d-LIVER targets sensor-based monitoring of patient health status at home, concentrating on continuous monitoring of physiological parameters and discrete measurement of a defined set of biochemical species. d-LIVER also targets remote monitoring and control of the bio-artificial liver and communication with patient sensor networks and hospital information systems. Systems will be capable of remote, secure communication of the status of both the patient and the bio-artificial liver to central clinical services such that they can schedule swift and beneficial treatment and remedial actions. In this way d-LIVER will provide fundamental advances in liver support by reducing hospitalisation costs while enhancing quality of care and, at the same time, reinforcing European leadership in Personal Health systems.In a parallel, high-risk, activity the production of human hepatocytes from pancreatic progenitor cells will be investigated. These would be ideal for use in d-LIVER systems since they may provide an unlimited supply of hepatocytes, which would overcome drawbacks associated with both primary hepatocytes and stem cells.
Fields of science
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorssmart sensors
- medical and health sciencesmedical biotechnologycells technologiesstem cells
- medical and health sciencesclinical medicinetransplantation
- medical and health sciencesmedical biotechnologytissue engineeringbioartificial liver
Call for proposal
FP7-ICT-2011-7
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Funding Scheme
CP - Collaborative project (generic)Coordinator
NE1 7RU Newcastle Upon Tyne
United Kingdom
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Participants (14)
2000 Neuchatel
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Participation ended
55129 Mainz
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12101 BERLIN
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12161 BERLIN
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50997 KOELN
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80686 Munchen
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10117 Berlin
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29590 Malaga
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43003 Tarragona
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75015 PARIS 15
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20100 Rozzano (Mi)
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Participation ended
11020 ARNAD
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7034 Trondheim
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TW1 4JX Twickenham Middlesex
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