Final Report Summary - NEUROVASCULAR LINK (Role of the vasculature in neuronal migration. 'The neurovascular link')
Many neurological and psychiatric diseases have a vascular component but there is little scientific progress concerning the molecular players that regulate both the vascular and the nervous system. Therefore, from our findings emerge a novel molecule involved in angiogenesis which might have a potential therapeutic application in vascular related diseases of the CNS. Furthermore, its participation in blood brain barrier integrity opens the possibility to be used as pharmacological tool to regulate the blood brain barrier permeability. Overall, our data has a high impact in the current knowledge of CNS development and our findings might be transferred to the development of new pharmacological drugs for neurological and psychiatric pathologies.