Project description Challenging current ThinkingMagnetic Nano Actuators for Quantitative Analysis Show the project objective Hide the project objective The MANAQA project is a multidisciplinary approach that combines innovative technologies emerging from different fields including nanotechnology, biochemistry, and nanorobotics. The strategy that will be exploited is based on a recently developed 5-DOF magnetic manipulation system combined with an atomic force microscope (AFM) system and functionalized magnetic nanowires. The fusion of these technologies has the potential to revolutionize many aspects of single-molecule manipulation and measurement. Information related to the structure and physical properties of macromolecules (i.e. proteins, polynucleotides) will be obtained. In a typical experiment, a molecule will be regiospecifically attached between a magnetic nanowire and the tip of an AFM cantilever. The extremely small footprint of the magnetic nanowire and the accuracy of a five degree-of-freedom magnetic manipulation system will allow high-resolution and stable force control on the molecule. The mechanical response of the molecule will be monitored using the AFM cantilever. Moreover, the system will be capable of measuring the electrical parameters of the nanowire-molecule hybrid. The success of this proposal will lead to long time-scale, low drift experiments that will provide invaluable insights on mechanisms governing conformational changes in single macromolecules by elucidating protein folding/unfolding/refolding trajectories at a low-force regime. This will contribute to the long-term vision of MANAQA of establishing a biomolecular measurement platform with extended capabilities. MANAQA opens new avenues in disciplines such as biochemistry, pharmacy, and biomedicine. The development of new miniaturized electronic devices within the scope of MANAQA project with single chemical entities integrated as their components will revolutionize the field of Information and Communication Technologies (ICT). Fields of science natural scienceschemical sciencesanalytical chemistryquantitative analysisengineering and technologynanotechnologynatural sciencesphysical sciencesopticsmicroscopynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsprotein foldingmedical and health sciencesbasic medicinepharmacology and pharmacy Programme(s) FP7-ICT - Specific Programme "Cooperation": Information and communication technologies Topic(s) ICT-2011.9.1 - Challenging current Thinking Call for proposal FP7-ICT-2011-C See other projects for this call Funding Scheme CP - Collaborative project (generic) Coordinator EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Address Raemistrasse 101 8092 Zuerich Switzerland See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Salvador Pané Vidal (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 774 124,00 Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all HIRTENBERGER ENGINEERED SURFACES GMBH Austria EU contribution € 307 900,00 Address Leobersdorfer strasse 31-33 2552 Hirtenberg See on map Region Ostösterreich Niederösterreich Niederösterreich-Süd Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Wolfgang Hansal (Dr.) Links Contact the organisation Opens in new window Website Opens in new window AEON SCIENTIFIC AG Switzerland EU contribution € 462 298,00 Address Tannenstrasse 3 8092 Zurich See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Dominik Bell (Dr.) Links Contact the organisation Opens in new window JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG Germany EU contribution € 214 161,00 Address Sanderring 2 97070 Wuerzburg See on map Region Bayern Unterfranken Würzburg, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Christian Gloggengiesser (Mr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITAT AUTONOMA DE BARCELONA Spain EU contribution € 449 633,00 Address Edif a campus de la uab bellaterra cerdanyola v 08193 Cerdanyola del valles See on map Region Este Cataluña Barcelona Activity type Higher or Secondary Education Establishments Administrative Contact Francisca Rabadán Sotos (Ms.) Links Contact the organisation Opens in new window Website Opens in new window BOGAZICI UNIVERSITESI Türkiye EU contribution € 567 186,00 Address Bebek 34342 Istanbul See on map Region İstanbul İstanbul İstanbul Activity type Higher or Secondary Education Establishments Administrative Contact Hamdi Torun (Prof.) Links Contact the organisation Opens in new window Website Opens in new window
