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Acute Inflammation Resolution by Soluble Human Inhibitory Protein

Obiettivo

"Acute inflammatory processes are associated with infections as well as autoimmune flares at the basis of a variety of human diseases. While the molecular components and the logic of pro-inflammatory program are relatively well understood, less is known about the molecular mechanism of resolution, governing the termination of inflammatory responses. In the course of carrying out the i-FIVE ERC grant project plan, we identified a novel, secreted, soluble enzyme as a negative regulator of pro-inflammatory immunity receptors. Here we propose a defined and focused set of measures aimed at obtaining solid evidence for therapeutic feasibility of this novel biological agent in resolving inflammatory processes as well as for the securing of intellectual property. The AIRSHIP workplan proposes to obtain enough purified, soluble, endotoxin-free, active and glycosylated protein material to execute two critical tests, one monitoring the inflammatory response in human cells, and one addressing beneficiary effects in a lung murine infection model. Armed with such a successful proof of concept package and having strategically positioned and secured our intellectual property rights we would be determined to embark into an ambitious commercialization initiative."

Invito a presentare proposte

ERC-2011-PoC
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Istituzione ospitante

CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH
Contributo UE
€ 150 000,00
Indirizzo
LAZARETTGASSE 14 AKH BT 25.3
1090 Wien
Austria

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Regione
Ostösterreich Wien Wien
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Sigrid Strodl (Ms.)
Collegamenti
Costo totale
Nessun dato

Beneficiari (1)