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Aza-Claisen-Sakurai Approach to Cyclopentylamines

Objective

"Cyclopentylamines are ubiquitous compounds within nature and many pharmaceutical products. Their synthesis can be problematic with length and unselective sequences plaguing them. We aim to overcome this shortcoming by developing a new approach whereby we couple two well known reactions; the Aza-Claisen (or Aza-Cope) rearrangement and the Sakurai allylation.
The expected outcomes of this research are a new method which is both rapid and selective for the synthesis of cyclopentylamines. We also intend to achieve the total synthesis of the compound (-)-Altemicidin, a highly substituted cyclopentylamine which exhibits potent antitumor and acaricidal properties. Any compounds produced will be screened against various disease states either here at Queen’s using the Centre for Cancer Research and Cell Biology or with our academic and industrial partners."

Call for proposal

FP7-PEOPLE-2011-IIF
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Funding Scheme

MC-IIF - International Incoming Fellowships (IIF)

Coordinator

THE QUEEN'S UNIVERSITY OF BELFAST
Address
University Road Lanyon Building
BT7 1NN Belfast
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 209 033,40
Administrative Contact
Pauline Mccann (Ms.)