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Aza-Claisen-Sakurai Approach to Cyclopentylamines

Ziel

"Cyclopentylamines are ubiquitous compounds within nature and many pharmaceutical products. Their synthesis can be problematic with length and unselective sequences plaguing them. We aim to overcome this shortcoming by developing a new approach whereby we couple two well known reactions; the Aza-Claisen (or Aza-Cope) rearrangement and the Sakurai allylation.
The expected outcomes of this research are a new method which is both rapid and selective for the synthesis of cyclopentylamines. We also intend to achieve the total synthesis of the compound (-)-Altemicidin, a highly substituted cyclopentylamine which exhibits potent antitumor and acaricidal properties. Any compounds produced will be screened against various disease states either here at Queen’s using the Centre for Cancer Research and Cell Biology or with our academic and industrial partners."

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2011-IIF
Andere Projekte für diesen Aufruf anzeigen

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Koordinator

THE QUEEN'S UNIVERSITY OF BELFAST
Adresse
University road lanyon building
BT7 1NN Belfast
Vereinigtes Königreich

Auf der Karte ansehen

Region
Northern Ireland Northern Ireland Belfast
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Pauline Mccann (Ms.)
Links
EU-Beitrag
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