Objetivo "Cancer is one of the most common reasons for death of people living in the developed countries. There were an estimated 3.2 million new cases of cancer and 1.7 million deaths in the year 2008 in Europe. Melanoma is a form of skin cancer caused by mutation of melanocytes in the skin. Common cancer therapy is not effective in treatment of metastatic melanoma. The survival rate of patients with this form of the disease is very low, indicating the need for development of new therapeutic options.The proposed research aims towards developing vaccination strategies that can be used for prevention or therapy of melanoma. Recent work in the field of cancer vaccination indicates high potential to improve and prolong the life of the patients. In the proposed research, the use of a new and very safe vaccine vector based on the modified lymphocytic choriomeningitis virus (rLCMV) for fight against cancer will be elucidated. The roll of immune cells to break the normal tolerance of the organism to tumour cells will be investigated and characterised. By conducting this research, not only cancer vaccination will be brought closer to application in patients, but additional insight into the mechanisms underlying immune tolerance against cancer will be gained. Cancer vaccination is a very timely scientific field and progress in this area will be noticed by the general public worldwide.The research will be conducted in the Dermatology Department at the University Hospital of Lausanne, Switzerland. The researcher is from Germany and has been working in the Department of Virology at the Bernhard-Nocht-Institute for Tropical Medicine in Hamburg. By performing the proposed research, the applicant will get additional interdisciplinary training on immunological methods and vaccination strategies. By adding these competencies, he will afterwards be able to establish his own work group focussing on viral pathogenesis and vaccination at a European research institute or university." Ámbito científico medical and health scienceshealth sciencestropical medicinenatural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesclinical medicinedermatologymedical and health sciencesclinical medicineoncologyskin cancermelanomamedical and health sciencesbasic medicineimmunology Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2011-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Convocatoria de propuestas FP7-PEOPLE-2011-IEF Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IEF - Intra-European Fellowships (IEF) Coordinador CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS Aportación de la UE € 192 622,20 Dirección RUE DU BUGNON 21 1011 Lausanne Suiza Ver en el mapa Región Schweiz/Suisse/Svizzera Région lémanique Vaud Tipo de actividad Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Contacto administrativo Lukas Flatz (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
