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Protein biochip array technology for diagnosis of Alzheimer's disease in blood platelets

Ziel

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with an ever-increasing incidence in the aged population. However, there is no definitive diagnostic test for Alzheimer's disease. AD patients are only probably detected at a progressed stage of the disease when neurodegeneration already occurred and the possibilities of treatment are reduced. In the proposed project, the Medical University of Vienna in Austria and the diagnostic company Randox Laboratories Ltd. in the UK join their expertise to develop a blood test for AD with the potential scientific background that blood platelets mirror AD-related alteration of the central nervous system.

In a clinical study the University has already identified 21 new AD-specific platelet proteins by difference two dimensional gel electrophoresis (DIGE). The proposed project combines the brand-new CyDye DIGE proteomic method with innovative Protein Biochip Array Technology of the Company. It aims to develop a Biochip, which detects the AD-specific proteins in blood platelets. An intensive transfer of knowledge between the two partners is necessary to achieve this goal. Mutual exchange of researchers for two years would accelerate the development of a diagnostic AD Biochip. University researchers will participate in production of antibodies and in the setup of a Protein Biochip Array at the Company. Company's researchers will learn platelet preparation, evaluate antibodies and clinical evaluation of the experimental Biochips at the University.

This exchange of researchers will overcome the gap between academia and industry. The techniques developed in the course of this collaboration will open new possibilities, which go far beyond the proposed project. This includes analysis of platelets from patients with other diseases such as diabetes or cardiovascular disease as well as analysis of other blood cells. Thus, the proposed project will constitute the basis for lasting inter-sectorial research collaboration.

Wissenschaftliches Gebiet (EuroSciVoc)

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Aufforderung zur Vorschlagseinreichung

FP6-2004-MOBILITY-3
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

TOK - Marie Curie actions-Transfer of Knowledge

Koordinator

MEDICAL UNIVERSITY OF VIENNA
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