Objective
Understanding membrane protein structure, interaction between these proteins and lipids, and how membrane proteins assemble in the membrane are as of yet unsolved problems of structural biology. This proposal aims to further our understanding in these areas by uniquely combining structural and biophysical data obtained from nuclear magnetic resonance experiments (Straus` area of expertise) with neutron methods, such as small angle neutron scattering (SANS), reflectometry, and neutron diffraction (Forsyth`s and other ILL members` area of research). Specifically, the team will focus their attention on three areas: 1) membrane perturbing antibiotic structure; 2) interaction of lipopeptides with the essential bacterial cell wall biosynthesis component lipid II; and 3) the assembly of membrane proteins in lipids, as studied using the tractable system of B5 filamentous bacteriophage. The proposed projects will not only enable Straus to expand her repertoire in structural methods by exposing her to a host of neutron methodology, but will also cement a strong partnership between Canada and France. The projects will also involve the close collaboration of a number of research groups in France and Germany: the group of Michel Gauthier in Nantes, a leading expert in B5 filamentous bacteriophage and the group of Hans-Georg Sahl in Bonn, who have worked extensively on characterizing interactions between lipopeptides and lipid II. The interdisciplinary nature of the proposed work and the strength of the team will ensure success on all fronts.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences biochemistry biomolecules lipids
- natural sciences biological sciences molecular biology structural biology
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IIF
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
38000 Grenoble
France
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