Gold(I)-catalyzed decarboxylation in direct decarboxylative C-H arylation

Project Information

AuPdCHARYL

Grant agreement ID: 300763

Project closed

Start date 1 September 2012

End date 31 August 2014

Funded under

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Total cost € 200 371,80

EU contribution € 200 371,80

Coordinated by

QUEEN MARY UNIVERSITY OF LONDON
United Kingdom

Objective

In the present research project we propose the development of new and innovative methodologies for organic synthesis, namely biaryl synthesis, by the combination of different metal-promoted processes. More specifically, the project will be built up on the very efficient procedure for gold-promoted decarboxylation of aromatic carboxylic acids, recently developed by the host group, giving place easily to arylgold(I) species.
As we detail below, the transmetallation of these aryl units from gold to other metal (likely palladium) capable of performing an orthogonal transformation as C–H activation would allow the direct cross-coupling of (hetero)arenes (via C–H activation) and aromatic carboxylic acids (via C–CO2H activation, see Scheme 1) without any pre-functionalization.
Such a methodology will significantly improve the current methodologies for the synthesis of biaryl motifs (ubiquitous in natural products, pharmaceuticals and organic materials) offering a more direct, economic and significantly greener approach. Replacing the use of organometallic compounds (frequently expensive, not trivial to prepare and giving place to large amounts of metal salt residues) by carboxylic acids (common functional groups in organic compounds, giving place to only CO2 as side product) will make cross-coupling processes more applicable both at laboratory and industrial scales and will very importantly reduce –virtually eliminate– their environmental impact.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.

• natural sciences › chemical sciences › organic chemistry › organic acids
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs
• natural sciences › chemical sciences › inorganic chemistry › organometallic chemistry
• natural sciences › chemical sciences › inorganic chemistry › transition metals

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Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Topic(s)

• FP7-PEOPLE-2011-IEF - Marie-Curie Action: "Intra-European fellowships for career development"

Call for proposal

FP7-PEOPLE-2011-IEF
See other projects for this call

Funding Scheme

MC-IEF - Intra-European Fellowships (IEF)

Coordinator

QUEEN MARY UNIVERSITY OF LONDON

• EU contribution: € 200 371,80
• Address: 327 MILE END ROAD ; E1 4NS London ; United Kingdom
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data