Objective
The hippocampal-entorhinal circuit is critical for the formation of new episodic memories, or memories of events that happen in a specific place and time. The discovery of cells in this circuit that respond to the animal's location in the environment suggests that these cells create a spatial context for such memories. Within this broad neural circuit, five key cell types have been described: place cells, grid cells, head direction cells, border cells, and cells that respond to a conjunction of these features. However, the mechanisms behind the generation of each firing pattern, and the function of each cell type, remain to be determined. Models have hypothesized that multi-peaked 'grid' responses are generated in layer II of the medial entorhinal cortex and converted into single-peaked 'place' responses in the hippocampus. Testing these models requires the capability to selectively manipulate individual elements of the circuit. The following experiments combine the cellular specificity of transgenic mice with novel optogenetic and pharmocogenetic tools to inactivate layer II of the medial entorhinal cortex while simultaneously recording ensembles of neurons in the entorhinal cortex or hippocampus. This genetic dissection will shed light on the basic operational principles of the circuit, and help distinguish between models of hippocampal-entorhinal interactions. Understanding the basic performance of the circuit will provide clues into how the circuit might malfunction in patients afflicted with Alzheimer's disease or epilepsy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology epilepsy
- natural sciences biological sciences neurobiology cognitive neuroscience
- medical and health sciences basic medicine neurology dementia alzheimer
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
7491 Trondheim
Norway
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.