Objectif Placental malaria, a special form of malaria targeting pregnant women, causes the death of 200,000 infants and 10,000 pregnant women each year. Placental malaria has no sustainable cure. The overall success criterion of the proposed project is to enable the manufacture of a vaccine, which protects fetus and mother against the adverse effects of malaria during pregnancy. Administered to women before they get pregnant the vaccine should induce antibodies that prevent the binding of malaria parasites in the placenta. Vaccine development is facilitated by the availability of an in vitro assay that predicts clinical immunity. With this proposal, we seek funding to produce the first placental malaria vaccine and perform the first clinical studies in humans. In parallel, we will prepare a field site and a protocol for a phase II study in African women. The partners behind the application have secured funding for ongoing work to down-select the current VAR2CSA lead antigens and to produce GLP batch protein for toxicology studies in animals, prior to the initiation of the work proposed here. Under the proposed FP7 project an SME, ExpreS2ion Biotechnologies will optimize production and purification of the vaccine. ExpreS2ion Biotechnologies operates a unique expression platform and this project will enable the company to expand their business into downstream process development. The academic partners are strong. Researchers at University of Copenhagen, (UCPH) originally discovered the vaccine protein and they have been collaborating with Institut de Recherche pour le Developpement (IRD) and Université d'Abomey-Calavi (UAC) to optimize vaccine antigens and to prepare sites for clinical testing. The European Vaccine Initiative (EVI) will provide product management and coordinate execution of the phase I clinical trial. Thus, this study will provide a product to continue into efficacy studies in Africa, which could be initiated shortly after the end of the project. Champ scientifique medical and health scienceshealth sciencesinfectious diseasesmalarianatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesmedical and health sciencesclinical medicineobstetricsmedical and health sciencesclinical medicineembryology Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Thème(s) HEALTH.2012.2.3.2-3 - Prevention and treatment for HIV/AIDS, malaria and tuberculosis Appel à propositions FP7-HEALTH-2012-INNOVATION-1 Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur KOBENHAVNS UNIVERSITET Contribution de l’UE € 2 096 620,00 Adresse NORREGADE 10 1165 Kobenhavn Danemark Voir sur la carte Région Danmark Hovedstaden Byen København Type d’activité Higher or Secondary Education Establishments Contact administratif Tine Mathiesen (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (5) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire EXPRES2ION BIOTECHNOLOGIES APS Danemark Contribution de l’UE € 996 648,00 Adresse AGERN ALLE 1 2970 Horsholm Voir sur la carte Région Danmark Hovedstaden Nordsjælland Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Willem Adriaan De Jongh (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT France Contribution de l’UE € 488 960,00 Adresse BOULEVARD DE DUNKERQUE 44 CS 90009 13572 Marseille Voir sur la carte Région Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône Type d’activité Research Organisations Contact administratif Jean Albergel (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée EUROPEAN VACCINE INITIATIVE EWIV Allemagne Contribution de l’UE € 435 296,58 Adresse VOSSSTRASSE 2 GEB 4040 69115 Heidelberg Voir sur la carte Région Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Type d’activité Research Organisations Contact administratif Sten Larsen (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITE D'ABOMEY-CALAVI Bénin Contribution de l’UE € 904 056,00 Adresse CAMPUS UNIVERSITAIRES D ABOMEY 01 Abomey Calavi Voir sur la carte Type d’activité Higher or Secondary Education Establishments Contact administratif Cynel Kahoun (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée EBERHARD KARLS UNIVERSITAET TUEBINGEN Allemagne Contribution de l’UE € 1 013 400,00 Adresse GESCHWISTER-SCHOLL-PLATZ 72074 Tuebingen Voir sur la carte Région Baden-Württemberg Tübingen Tübingen, Landkreis Type d’activité Higher or Secondary Education Establishments Contact administratif Stefanie Bolte (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
