Obiettivo Placental malaria, a special form of malaria targeting pregnant women, causes the death of 200,000 infants and 10,000 pregnant women each year. Placental malaria has no sustainable cure. The overall success criterion of the proposed project is to enable the manufacture of a vaccine, which protects fetus and mother against the adverse effects of malaria during pregnancy. Administered to women before they get pregnant the vaccine should induce antibodies that prevent the binding of malaria parasites in the placenta. Vaccine development is facilitated by the availability of an in vitro assay that predicts clinical immunity. With this proposal, we seek funding to produce the first placental malaria vaccine and perform the first clinical studies in humans. In parallel, we will prepare a field site and a protocol for a phase II study in African women. The partners behind the application have secured funding for ongoing work to down-select the current VAR2CSA lead antigens and to produce GLP batch protein for toxicology studies in animals, prior to the initiation of the work proposed here. Under the proposed FP7 project an SME, ExpreS2ion Biotechnologies will optimize production and purification of the vaccine. ExpreS2ion Biotechnologies operates a unique expression platform and this project will enable the company to expand their business into downstream process development. The academic partners are strong. Researchers at University of Copenhagen, (UCPH) originally discovered the vaccine protein and they have been collaborating with Institut de Recherche pour le Developpement (IRD) and Université d'Abomey-Calavi (UAC) to optimize vaccine antigens and to prepare sites for clinical testing. The European Vaccine Initiative (EVI) will provide product management and coordinate execution of the phase I clinical trial. Thus, this study will provide a product to continue into efficacy studies in Africa, which could be initiated shortly after the end of the project. Campo scientifico scienze mediche e della salutescienze della salutemalattie infettivemalariascienze naturaliscienze biologichebiochimicabiomolecoleproteinescienze mediche e della salutemedicina di basefarmacologia e farmaciafarmacivacciniscienze mediche e della salutemedicina clinicaostetriciascienze mediche e della salutemedicina clinicaembriologia Programma(i) FP7-HEALTH - Specific Programme "Cooperation": Health Argomento(i) HEALTH.2012.2.3.2-3 - Prevention and treatment for HIV/AIDS, malaria and tuberculosis Invito a presentare proposte FP7-HEALTH-2012-INNOVATION-1 Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore KOBENHAVNS UNIVERSITET Indirizzo Norregade 10 1165 Kobenhavn Danimarca Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments projects.administrative_contact Tine Mathiesen (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Contributo UE € 2 096 620,00 Partecipanti (5) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto EXPRES2ION BIOTECHNOLOGIES APS Danimarca Contributo UE € 996 648,00 Indirizzo Agern alle 1 2970 Horsholm Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) projects.administrative_contact Willem Adriaan De Jongh (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT Francia Contributo UE € 488 960,00 Indirizzo Boulevard de dunkerque 44 cs 90009 13572 Marseille Mostra sulla mappa Tipo di attività Research Organisations projects.administrative_contact Jean Albergel (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window EUROPEAN VACCINE INITIATIVE EWIV Germania Contributo UE € 435 296,58 Indirizzo Vossstrasse 2 geb 4040 69115 Heidelberg Mostra sulla mappa Tipo di attività Research Organisations projects.administrative_contact Sten Larsen (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window UNIVERSITE D'ABOMEY-CALAVI Benin Contributo UE € 904 056,00 Indirizzo Campus universitaires d abomey 01 Abomey calavi Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments projects.administrative_contact Cynel Kahoun (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window EBERHARD KARLS UNIVERSITAET TUEBINGEN Germania Contributo UE € 1 013 400,00 Indirizzo Geschwister-scholl-platz 72074 Tuebingen Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments projects.administrative_contact Stefanie Bolte (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window
