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Detection of persistent infections by human papillomaviruses

Objective

The SMEs MIKROGEN and BIOSYNEX are well established in the field of diagnostic tests for infectious diseases in humans and perform active research into innovative products. As a critical step to get access to the lucrative market of diagnostic kits for the detection of persistent infections by human papillomaviruses (HPV), the SMEs teamed up with partner UIBK who developed a unique set of immunological tools suitable for this purpose, and two leading European gynecological clinics with longstanding interest in improving clinical management of HPV-associated diseases. Currently used diagnostic tools can detect HPV DNA in cervical smears but fall short of discriminating between transient infections which can spontaneously regress and persistent infections, which have a high chance to progress to high-grade squamous intraepithelial lesions. At this point, the PIPAVIR consortium comes in with the proposal to develop and validate a new diagnostic test for progressive infectious diseases that allows detection, by sandwich-ELISA, of HPV E7 proteins in cervical smears, as markers specific for persistent infections with bad prognosis. In addition, it is planned to develop and validate a diagnostic test strip for rapid detection of viral E7 proteins in cervical smears, most appropriate for alternative diagnostic procedures, such as self-sampling, as well as for the use in low-resource settings. As a major innovative feature, both proposed products use as molecular markers virus-encoded proteins closely related to infection-associated pathology, rather than just the presence of viral DNA or any surrogate markers. Based on the potential of the technology to meet a real clinical need, it can be anticipated that the ability of the participating SME partners to provide and market such superior diagnostic tools will create great business opportunities.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/dna
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /social sciences/economics and business/business and management/commerce

Call for proposal

FP7-HEALTH-2012-INNOVATION-2
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITAET INNSBRUCK
Address
Innrain 52
6020 Innsbruck
Austria
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 873 844,60
Administrative Contact
Pidder Jansen-Dürr (Dr.)

Participants (5)

MIKROGEN GMBH
Germany
EU contribution
€ 1 319 340,02
Address
Floriansbogen 2-4
82061 Neuried
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Oliver Boecher (Dr.)
BIOSYNEX SA
France
EU contribution
€ 610 334,38
Address
Rue Ettore Bugatti 12
67038 Strasbourg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Tieleman Remco (Mr.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 498 600
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eveline Fräßdorf
ARISTOTELIO PANEPISTIMIO THESSALONIKIS
Greece
EU contribution
€ 313 160
Address
Kedea Building, Tritis Septemvriou, Aristotle Univ Campus
54636 Thessaloniki
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Petridou Georgia (Ms.)
OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN

Participation ended

Austria
Address
Dr. Ignaz Seipel-platz 2
1010 Wien
Activity type
Research Organisations
Administrative Contact
Pidder Jansen-Dürr (Dr.)