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Integrated European –omics research project for diagnosis and therapy in rare neuromuscular and neurodegenerative diseases

Ziel

Neurodegenerative (ND) and neuromuscular (NM) disease is one of the most frequent classes of rare diseases, affecting life and mobility of 500,000 patients in Europe and millions of their caregivers, family members and employers. This NEUROMICS project brings together the leading research groups in Europe, five highly innovative SMEs and relevant oversea experts using the most sophisticated Omics technologies to revolutionize diagnostics and to develop pathomechanism-based treatment for ten major ND and NM diseases. Specifically we aim to:
(i) use next generation WES to increase the number of known gene loci for the most heterogeneous disease groups from about 50% to 80%,
(ii) increase patient cohorts by large scale genotyping by enriched gene variant panels and NGS of so far unclassified patients and subsequent phenotyping,
(iii) develop biomarkers for clinical application with a strong emphasis on presymptomatic utility and cohort stratification,
(iv) combine -omics approaches to better understand pathophysiology and identify therapeutic targets,
(v) identify disease modifiers in disease subgroups cohorts with extreme age of onset
(vi) develop targeted therapies (to groups or personalized) using antisense oligos and histone deacetylase inhibitors, translating the consortiums expertise in clinical development from ongoing trials toward other disease groups, notably the PolyQ diseases and other NMD.
To warrant that advances affect a large fraction of patients we limited the selection to a number of major categories, some of which are in a promising stage of etiological and therapeutic research while some others are in great need of further classification. The efforts will be connected through a NEUROMICS platform for impact, communication and innovation that will provide tools and procedures for ensuring trial-readiness, WP performance, sustainability, interaction with the chosen Support IRDiRC and RD-Connect project and involvement of stakeholders in the NDD/NMD field.

Aufforderung zur Vorschlagseinreichung

FP7-HEALTH-2012-INNOVATION-1
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Koordinator

EBERHARD KARLS UNIVERSITAET TUEBINGEN
Adresse
Geschwister-scholl-platz
72074 Tuebingen
Deutschland
Aktivitätstyp
Higher or Secondary Education Establishments
EU-Beitrag
€ 1 548 720,60
Kontakt Verwaltung
Holm Graessner (Dr.)

Beteiligte (18)

ACADEMISCH ZIEKENHUIS LEIDEN
Niederlande
EU-Beitrag
€ 747 400
Adresse
Albinusdreef 2
2333 ZA Leiden
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
R Esveld (Mr.)
KLINIKUM DER UNIVERSITAET ZU KOELN
Deutschland
EU-Beitrag
€ 796 300
Adresse
Kerpener Strasse 62
50937 Koeln
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Brunhilde Wirth (Prof.)
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
EU-Beitrag
€ 1 020 478
Adresse
Kings Gate
NE1 7RU Newcastle Upon Tyne
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Amanda Gregory (Dr.)
DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV
Deutschland
EU-Beitrag
€ 367 000,80
Adresse
Venusberg-campus 1/99
53127 Bonn
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Annette Schoen (Mrs.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU-Beitrag
€ 952 601
Adresse
Gower Street
WC1E 6BT London
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Greta Borg-Carbott (Mrs.)
UNIVERSITE D'AIX MARSEILLE
Frankreich
EU-Beitrag
€ 528 000
Adresse
Boulevard Charles Livon 58
13284 Marseille
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Céline Damon (Ms.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Frankreich
EU-Beitrag
€ 993 999,60
Adresse
Rue De Tolbiac 101
75654 Paris
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Isabelle Verdier (Mrs.)
VIB VZW
Belgien
EU-Beitrag
€ 613 200
Adresse
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Rik Audenaert (Mr.)
UNIVERSITA DEGLI STUDI DI MILANO
Italien
EU-Beitrag
€ 246 000
Adresse
Via Festa Del Perdono 7
20122 Milano
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Elena Cattaneo (Prof.)
UNIVERSITA DEGLI STUDI DI FERRARA
Italien
EU-Beitrag
€ 244 000
Adresse
Via Ariosto 35
44121 Ferrara
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Francesco Di Virgilio (Prof.)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU-Beitrag
€ 246 000
Adresse
Trinity Lane The Old Schools
CB2 1TN Cambridge
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Renanta Schaeffer (Ms.)
ISLENSK ERFDAGREINING EHF
Island
EU-Beitrag
€ 2 191 500
Adresse
Sturlugotu 8
101 Reykjavik
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Frosti Jonsson (Mr.)
ARIADNE DIAGNOSTICS LLC
Vereinigte Staaten
EU-Beitrag
€ 480 000
Adresse
Key West Ave 9430 Suite 115
20850 Rockville
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Elena Schwartz (Dr.)
PROFILOMIC SA
Frankreich
EU-Beitrag
€ 492 400
Adresse
Rue D Aguesseau 31
92100 Boulogne Billancourt
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Bruno Corman (Mr.)
AGILENT TECHNOLOGIES SWEDEN AB
Schweden
EU-Beitrag
€ 200 400
Adresse
Kronborgsgrand 23
SE16494 Kista
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Laura Bernasconi (Ms.)
BIO-PRODICT BV
Niederlande
EU-Beitrag
€ 252 000
Adresse
Nieuwe Marktstraat 54
6511 AA Nijmegen
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Henk-Jan Joosten (Dr.)
THE UNIVERSITY OF WESTERN AUSTRALIA
Australien
Adresse
Stirling Higway 35
6009 Crawley
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Robert Roche (Mr.)
UNIVERSITAETSKLINIKUM FREIBURG
Deutschland
EU-Beitrag
€ 80 000
Adresse
Hugstetter Strasse 49
79106 Freiburg
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Gerhard Henninger (Mr.)