Obiettivo
The overall goal with INFECT is to advance our understanding of the pathophysiological mechanisms, prognosis, and diagnosis of the multifactorial highly lethal NSTIs. The fulminant course of NSTIs (in the order of hours) demands immediate diagnosis and adequate interventions in order to salvage lives and limbs. However, diagnosis and management are difficult due to heterogeneity in clinical presentation, in co-morbidities and in microbiological aetiology. Thus, there is an urgent need for novel diagnostic and therapeutic strategies in order to improve outcome of NSTIs. To achieve this, a comprehensive and integrated knowledge of diagnostic features, causative microbial agent, treatment strategies, and pathogenic mechanisms (host and bacterial disease traits and their underlying interaction network) is required. INFECT is designed to obtain such insights through an integrated systems biology approach in patients and different clinically relevant experimental models.
Specific objectives of INFECT are to:
1. Unravel specific mechanisms underlying diseases signatures though a bottom-up systems approach applied to clinically relevant experimental settings
2. Apply a top-down systems biology approach to NSTI patient samples to pin-point key host and pathogen factors involved in the onset and development of infection
3. Identify and quantify disease signatures and underlying networks that contribute to disease outcome
4. Exploit identified disease traits for the innovation of optimized diagnostic tools
5. Translate the advanced knowledge generated into evidence-based guidelines for classification and management, and novel therapeutic strategies
We have gathered a team of multidisciplinary researchers, clinicians, SMEs and a patient organization, each with a unique expertise, technical platform and/or model systems that together provide the means to successfully conduct the multifaceted research proposed and efficiently disseminate/exploit the knowledge obtained.
Invito a presentare proposte
FP7-HEALTH-2012-INNOVATION-1
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Meccanismo di finanziamento
CP-IP - Large-scale integrating projectCoordinatore
17177 Stockholm
Svezia
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Partecipanti (15)
3400 Hillerod
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104 22 Stockholm
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37185 Karlskrona
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462 80 Vanersborg
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5020 Bergen
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Partecipazione conclusa
45221-0222 Cincinnati
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38124 Braunschweig
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6708 PB Wageningen
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69622 Villeurbanne Cedex
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12163 Berlin
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Partecipazione conclusa
4300 ST VALENTIN
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PR2 2XE PRESTON
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69978 Tel Aviv
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58202 8356 GRAND FORKS ND
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4300 St Valentin
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