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Diagnosis and Monitoring of Inflammatory and Arthritic diseases using a COmbined approach Based on Ultrasound, optoacoustic and hyperSpectral imaging

Objective

Rheumatoid arthritis (RA) and psoriasis arthritis (PSA) are destructive polyarthritic diseases having high incidence rates worldwide of about 1,5% and 0,5% respectively. Arthritis-related joint destruction leads to disabilities which result in a loss of patient’s quality of life, often include an inability to work and significant costs for healthcare systems. The functional outcome is strongly dependent on the time lag between the onset of the disease and the treatment beginning (ideally < 3-6 months). For early diagnosis allowing to improve the course of this devastating disease, sensitive and accurate diagnostic tools are required. Further, excellent image quality is needed for differentiated diagnosis (osteoarthritis vs RA or PSA) permitting the stratification of patient groups required for enabling a personalized therapeutical approach. Therefore, tools for early, precise and reliable diagnosis being affordable for screenings are of highest importance. Within IACOBUS, we suggest a new multimodal approach combining hyperspectral imaging with ultrasound (US) and optoacoustic (OA) techniques for diagnosis of arthritic diseases in finger joints. The proposed concept will allow the diagnosis and monitoring of arthritis based on imaging of early inflammation-induced hyperperfusion. Hyperspectral overview imaging for identification of suspicious joints will be combined with detailed high-resolution 3D imaging of affected joints (OA/US). Osteochondral information will be provided by high-frequency US while OA imaging will allow the high-sensitivity imaging of microvasculature in inflamed tissue. The consortium consisting of 4 SMEs and 3 academic partners will develop a novel non-invasive image-based diagnostic tool with significantly enhanced sensitivity for early arthritis symptoms and thereby allow to make use of the therapeutical window of opportunities. 50% of the overall project budget will go to SMEs which will ensure the exploitation of the developed platform.

Call for proposal

FP7-HEALTH-2012-INNOVATION-1
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Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Address
Hansastrasse 27C
80686 Munchen
Germany
Activity type
Research Organisations
EU contribution
€ 697 888
Administrative Contact
Andrea Zeumann (Ms.)

Participants (6)

NORSK ELEKTRO OPTIKK AS
Norway
EU contribution
€ 765 042
Address
Ostensjoveien 34
0667 Oslo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Peter Kaspersen (Mr.)
VERMON SA
France
EU contribution
€ 384 518
Address
67 Rue Fromentel
37000 Tours
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jean-Yves Corduan (Mr.)
NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU
Norway
EU contribution
€ 564 648
Address
Hogskoleringen 1
7491 Trondheim
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lise Lyngsnes Randeberg (Dr.)
JUSTUS-LIEBIG-UNIVERSITAET GIESSEN
Germany
EU contribution
€ 230 400
Address
Ludwigstrasse 23
35390 Giessen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christian Veldmann (Dr.)
EKSPLA UAB
Lithuania
EU contribution
€ 168 300
Address
Savanoriu Pr 231
02300 Vilnius
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Andrejus Michailovas (Dr.)
TP21 GMBH
Germany
EU contribution
€ 235 680
Address
Luisenstrasse 14
10117 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Petra Zalud (Dr.)