Objective Extensive clinical and epidemiological data clearly shows that chronic periodontal disease (PD), the most prevalent infectious inflammatory disease of mankind, is strongly linked to systemic inflammatory diseases such as cardiovascular diseases (CVD) , rheumatoid arthritis (RA) , and chronic obstructive pulmonary disease (COPD) . Taking into account that up to 30% of the adult population worldwide suffers from severe periodontitis , the impact of this disease on human health is immense and has been recognized by World Health Organization . Nevertheless, in many EU countries PD is a neglected disease, both by the population in general and health-care personnel. Often this negligence comes to the point that, like a hair-loss, the tooth-loss due to periodontitis is still considered as a normal inevitable event associated with aging. To combat this misconception and conceive novel approaches to prevent and/or treat CVD, RA, and COPD we will explore highly innovative ideas that these non-communicable diseases are at least aggravated, if not initiated, by periodontal infection.Results emanating from our project will: i) elucidate a relationship between the presence of specific periodontal pathogens and severity of systemic diseases; ii) show that extensive periodontal treatment improves clinical parameters of investigated systemic diseases; iii) reveal the impact of eradication of specific periodontal pathogen on the level of inflammatory markers; iv) develop novel, periodontal-pathogen specific bactericidal compounds based on periodontal glutaminyl cyclase (QC), the enzyme essential for these pathogens vitality.This will reduce mortality and ameliorated quality of life of CVD, RA, and COPD patients. All of these will be possible based on the knowledge of mechanisms beyond the causative links between specific pathogen driven periodontal disease and CVD, RA, and COPD revealed by research program outlined in this project. Fields of science medical and health sciencesclinical medicinecardiologycardiovascular diseasesmedical and health sciencesclinical medicineodontologyperiodontics Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2012.2.3.2-2 - Co-morbidity between infectious and non-communicable diseases Call for proposal FP7-HEALTH-2012-INNOVATION-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator UNIVERSITETET I BERGEN EU contribution € 1 108 000,00 Address Museplassen 1 5020 Bergen Norway See on map Region Norge Vestlandet Vestland Activity type Higher or Secondary Education Establishments Administrative Contact Liv-Grethe Gudmundsen (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all Jagiellonian University in Krakow Poland EU contribution € 586 120,00 Address Ul. golebia 24 31007 Krakow See on map Region Makroregion centralny Łódzkie Miasto Łódź Activity type Higher or Secondary Education Establishments Administrative Contact Agata Potempa (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AARHUS UNIVERSITET Denmark EU contribution € 558 042,00 Address Nordre ringgade 1 8000 Aarhus c See on map Region Danmark Midtjylland Østjylland Activity type Higher or Secondary Education Establishments Administrative Contact Pernille Leth Stentov (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ANAXOMICS BIOTECH SL Spain EU contribution € 299 660,00 Address Calle diputacio 237, p 1 pta 1 08007 Barcelona See on map Region Este Cataluña Barcelona Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Vesna Radovanovic (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution € 519 041,00 Address Calle serrano 117 28006 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Alberto Sereno Alvarez (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV Germany EU contribution € 484 510,00 Address Hansastrasse 27c 80686 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Andrea Zeumann (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KAROLINSKA INSTITUTET Sweden EU contribution € 532 800,00 Address Nobels vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Caroline Hamilton (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HADASSAH MEDICAL ORGANIZATION Israel EU contribution € 483 600,00 Address N/a 91120 Jerusalem See on map Activity type Higher or Secondary Education Establishments Administrative Contact Hadas Lemberg (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITETET I OSLO Norway EU contribution € 466 590,00 Address Problemveien 5-7 0313 Oslo See on map Region Norge Oslo og Viken Oslo Activity type Higher or Secondary Education Establishments Administrative Contact Per Arenfeldt Omdal (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF BIRMINGHAM United Kingdom EU contribution € 496 000,00 Address Edgbaston B15 2TT Birmingham See on map Region West Midlands (England) West Midlands Birmingham Activity type Higher or Secondary Education Establishments Administrative Contact May Chung (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAET BERN Switzerland EU contribution € 448 000,00 Address Hochschulstrasse 6 3012 Bern See on map Region Schweiz/Suisse/Svizzera Espace Mittelland Bern / Berne Activity type Higher or Secondary Education Establishments Administrative Contact Sigrun Eick (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data