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Enhanced exposure assessment and omic profiling for high priority environmental exposures in Europe

Objective

This project aims to predict individual disease risk related to the environment, by characterizing the external and internal exposome for common exposures (air and drinking water contaminants) during critical periods of life, including in utero. A large amount of health data is now available from longitudinal cohorts in both children and adults, with detailed information on risk factors, confounders and outcomes, but these are not well linked with environmental exposure data. The exposome concept refers to the totality of environmental exposures from conception onwards, and is a novel approach to studying the role of the environment in human disease. This project will move the field forward by utilising data on individual external exposome (including sensors, smartphones, geo-referencing, satellites), and omic profiles in an agnostic search for new and integrated biomarkers. These tools will be applied in both experimental short-term studies and long-term longitudinal studies in humans. The ultimate goal is to use the new tools in risk assessment and in the estimation of the burden of environmental disease. The involvement of two SMEs, one specialized in sensors and smartphone development, the other in complex data integration, will increase the chances of a successful impact on European Public Health. This multidisciplinary proposal combines:
• development of a general framework for the systematic measurement of the internal and external exposome in Europe in relation to air and water contamination, as a way to reduce uncertainty in risk assessment and to address the effects of mixtures and complex exposures;
• evaluation of health outcomes and key physiological changes in short-term studies (including a randomized trial) and life-course studies with a large amount of information on diet, physical activity and anthropometry;
• evaluation of the burden of disease in the European population, based on state-of-the-art assessment of population exposures.

Call for proposal

FP7-ENV-2012-two-stage
See other projects for this call

Coordinator

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 246 767,40
Administrative Contact
Tatjana Palalic (Ms.)

Participants (13)

FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL

Participation ended

Spain
EU contribution
€ 1 185 106
Address
Calle Doctor Aiguader 88
08003 Barcelona
Activity type
Research Organisations
Administrative Contact
Manolis Kogevinas (Prof.)
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 1 361 304
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Roel Vermeulen (Dr.)
CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER
France
EU contribution
€ 1 130 151,60
Address
150 Cours Albert Thomas
69372 Lyon Cedex 08
Activity type
Other
Administrative Contact
Olaf Kelm (Dr.)
FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA
Spain
Address
C Rossello 132 Planta 05
08036 Barcelona
Activity type
Research Organisations
Administrative Contact
Manolis Kogevinas (Prof.)
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 1 444 272
Address
Minderbroedersberg 4
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
René Reijnders (Mr.)
ETHNIKO IDRYMA EREVNON
Greece
EU contribution
€ 222 360
Address
Vas Konstantinou 48
11635 Athina
Activity type
Research Organisations
Administrative Contact
Ioanna Petrochilou (Mrs.)
SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT
Switzerland
EU contribution
€ 482 417
Address
Socinstrasse 57
CH-4002 Basel
Activity type
Research Organisations
Administrative Contact
Nicole Probst-Hensch (Prof.)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 632 318
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Labbett (Mr.)
GENEDATA AG
Switzerland
EU contribution
€ 461 380
Address
Margarethenstrasse 38
4053 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Timo Wittenberger (Dr.)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
United States
EU contribution
€ 245 450,80
Address
Franklin Street 1111, 12 Floor
94607 Oakland Ca
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jyl Baldwin (Ms.)
UNIVERSITY OF BRISTOL
United Kingdom
EU contribution
€ 77 830
Address
Beacon House Queens Road
BS8 1QU Bristol
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Elodie Mahieu-Wedande (Mrs.)
NTRAM GENERAL S.A.
Spain
EU contribution
€ 259 272
Address
Calle Victor Pradera 45
08940 Cornella De Llobregat Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Alicja Grzegorzek (Ms.)
UNIVERSITEIT HASSELT
Belgium
Address
Martelarenlaan 42
3500 Hasselt
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ilse Haeldermans (Dr.)