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Enhanced exposure assessment and omic profiling for high priority environmental exposures in Europe

Obiettivo

This project aims to predict individual disease risk related to the environment, by characterizing the external and internal exposome for common exposures (air and drinking water contaminants) during critical periods of life, including in utero. A large amount of health data is now available from longitudinal cohorts in both children and adults, with detailed information on risk factors, confounders and outcomes, but these are not well linked with environmental exposure data. The exposome concept refers to the totality of environmental exposures from conception onwards, and is a novel approach to studying the role of the environment in human disease. This project will move the field forward by utilising data on individual external exposome (including sensors, smartphones, geo-referencing, satellites), and omic profiles in an agnostic search for new and integrated biomarkers. These tools will be applied in both experimental short-term studies and long-term longitudinal studies in humans. The ultimate goal is to use the new tools in risk assessment and in the estimation of the burden of environmental disease. The involvement of two SMEs, one specialized in sensors and smartphone development, the other in complex data integration, will increase the chances of a successful impact on European Public Health. This multidisciplinary proposal combines:
• development of a general framework for the systematic measurement of the internal and external exposome in Europe in relation to air and water contamination, as a way to reduce uncertainty in risk assessment and to address the effects of mixtures and complex exposures;
• evaluation of health outcomes and key physiological changes in short-term studies (including a randomized trial) and life-course studies with a large amount of information on diet, physical activity and anthropometry;
• evaluation of the burden of disease in the European population, based on state-of-the-art assessment of population exposures.

Invito a presentare proposte

FP7-ENV-2012-two-stage
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Meccanismo di finanziamento

CP - Collaborative project (generic)

Coordinatore

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Indirizzo
South Kensington Campus Exhibition Road
SW7 2AZ London
United Kingdom

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Tatjana Palalic (Ms.)
Contributo UE
€ 1 246 767,40

Partecipanti (13)

FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL

Partecipazione conclusa

Spagna
Contributo UE
€ 1 185 106
Indirizzo
Calle Doctor Aiguader 88
08003 Barcelona

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Tipo di attività
Research Organisations
Contatto amministrativo
Manolis Kogevinas (Prof.)
UNIVERSITEIT UTRECHT
Paesi Bassi
Contributo UE
€ 1 361 304
Indirizzo
Heidelberglaan 8
3584 CS Utrecht

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Roel Vermeulen (Dr.)
CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER
Francia
Contributo UE
€ 1 130 151,60
Indirizzo
150 Cours Albert Thomas
69372 Lyon Cedex 08

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Tipo di attività
Research Organisations
Contatto amministrativo
Olaf Kelm (Dr.)
FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA
Spagna
Indirizzo
C Rossello 132 Planta 05
08036 Barcelona

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Tipo di attività
Research Organisations
Contatto amministrativo
Manolis Kogevinas (Prof.)
UNIVERSITEIT MAASTRICHT
Paesi Bassi
Contributo UE
€ 1 444 272
Indirizzo
Minderbroedersberg 4
6200 MD Maastricht

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
René Reijnders (Mr.)
ETHNIKO IDRYMA EREVNON
Grecia
Contributo UE
€ 222 360
Indirizzo
Vas Konstantinou 48
11635 Athina

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Tipo di attività
Research Organisations
Contatto amministrativo
Ioanna Petrochilou (Mrs.)
SCHWEIZERISCHES TROPEN UND PUBLIC HEALTH INSTITUT
Svizzera
Contributo UE
€ 482 417
Indirizzo
Kreuzstrasse 2
4123 Allschwil

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Tipo di attività
Research Organisations
Contatto amministrativo
Nicole Probst-Hensch (Prof.)
KING'S COLLEGE LONDON
United Kingdom
Contributo UE
€ 632 318
Indirizzo
Strand
WC2R 2LS London

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Paul Labbett (Mr.)
GENEDATA AG
Svizzera
Contributo UE
€ 461 380
Indirizzo
Margarethenstrasse 38
4053 Basel

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Timo Wittenberger (Dr.)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Stati Uniti
Contributo UE
€ 245 450,80
Indirizzo
Franklin Street 1111 12 Floor
94607 Oakland Ca

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Jyl Baldwin (Ms.)
UNIVERSITY OF BRISTOL
United Kingdom
Contributo UE
€ 77 830
Indirizzo
Beacon House Queens Road
BS8 1QU Bristol

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Elodie Mahieu-Wedande (Mrs.)
ATEKNEA SOLUTIONS CATALONIA, SA
Spagna
Contributo UE
€ 259 272
Indirizzo
Calle Victor Pradera 45
08940 Cornella De Llobregat Barcelona

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Alicja Grzegorzek (Ms.)
UNIVERSITEIT HASSELT
Belgio
Indirizzo
Martelarenlaan 42
3500 Hasselt

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Ilse Haeldermans (Dr.)