Objective NanoAthero aims to have demonstration of initial clinical feasibility of nanosystems for targeted imaging and treatment of advanced atherosclerotic disease in humans. The nanosystems are assemblies of following components: nanocarrier, targeting, imaging agent/drug. They have proven safety records, and strong preliminary in vitro and in vivo proofs of efficacy are available. Partners have patented and provided evidence of efficacy of carriers and ligands. Over 5 years, NanoAthero will integrate GMP production, the initiation of clinical investigations in high-risk patients, including the preparation of regulatory dossiers, risk and ethical assessments, and the evaluation of the performance of optimized diagnostic and therapeutic compounds. NanoAthero offers a unique opportunity for combining in-depth knowledge of nanocarrier bioengineering and production with state-of the art expertise in imaging and treatment of cardiovascular patients providing a full bench-to-bedside framework within one collaborative consortium of 16 partners from academia, a European association, SMEs and a large pharmaceutical company. NanoAthero gathers together leading chemists, engineers, pharmacists, biologists, toxicologists, clinicians, analysts, ethicists and key-opinion leaders in the field of cardiovascular medicine and early drug development.In NanoAthero, the nanocarriers carrying compounds to visualize thrombus or vulnerable plaques, or to deliver therapeutic agents should be suitable for proof-of-concept in patients. Phase I clinical trials targeting pivotal pathways in atherothrombosis will be performed with nanosystems for diagnosis and treatment of carotid atheroma. NanoAthero aims to propose nanosystems for thrombus imaging, stroke treatment and plaque stabilization in high-risk patients. Molecular imaging and therapeutic treatments in NanoAthero are based on feasible approaches. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesclinical medicinecardiologycardiovascular diseasesarteriosclerosismedical and health sciencesmedical biotechnologynanomedicinemedical and health sciencesbasic medicineneurologystroke Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP.2012.1.2-2 - Development and phase-I clinical trials of novel therapeutic nanotechnology-enabled systems for the diagnosis and treatment of atherosclerosis Call for proposal FP7-NMP-2012-LARGE-6 See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Address Rue de tolbiac 101 75654 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Dina Falkenreck (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 1 641 882,55 Participants (15) Sort alphabetically Sort by EU Contribution Expand all Collapse all ASSISTANCE PUBLIQUE HOPITAUX DE PARIS France EU contribution € 430 873,60 Address 55 boulevard diderot 75012 Paris See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Research Organisations Administrative Contact Alix Pillot (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window INSERM TRANSFERT SA France EU contribution € 612 161,10 Address 10 rue d'oradour-sur-glane - parisante campus 75015 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Catherine Clusel (Dr.) Links Contact the organisation Opens in new window Website Opens in new window ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Netherlands EU contribution € 894 116,80 Address Meibergdreef 15 1105AZ Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Gulseren Yalvac (Ms.) Links Contact the organisation Opens in new window Website Opens in new window MEDIZINISCHE UNIVERSITAT GRAZ Austria EU contribution € 525 701,20 Address Neue stiftingtalstrasse 6 8010 Graz See on map Region Südösterreich Steiermark Graz Activity type Higher or Secondary Education Establishments Administrative Contact Ingrid Reinprecht (Ms.) Links Contact the organisation Opens in new window Website Opens in new window SYDDANSK UNIVERSITET Denmark EU contribution € 160 400,40 Address Campusvej 55 5230 Odense m See on map Region Danmark Syddanmark Fyn Activity type Higher or Secondary Education Establishments Administrative Contact Arne Bækdal Hansen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITATSKLINIKUM ERLANGEN Germany EU contribution € 1 049 443,60 Address Maximiliansplatz 2 91054 Erlangen See on map Region Bayern Mittelfranken Erlangen, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Karin Heuchemer (Ms.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITEIT TWENTE Netherlands EU contribution € 687 522,75 Address Drienerlolaan 5 7522 NB Enschede See on map Region Oost-Nederland Overijssel Twente Activity type Higher or Secondary Education Establishments Administrative Contact Ferdinand Damhuis (Mr.) Links Contact the organisation Opens in new window Website Opens in new window MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Germany EU contribution € 203 000,00 Address Hofgartenstrasse 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Nadine Stolz (Ms.) Links Contact the organisation Opens in new window Website Opens in new window COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES France EU contribution € 1 285 035,00 Address Rue leblanc 25 75015 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Antoine Dupont (Mr.) Links Contact the organisation Opens in new window Website Opens in new window EUROPAISCHE STIFTUNG FUR KLINISCHE NANOMEDIZIN Switzerland EU contribution € 231 711,60 Address Alemannengasse 12 4016 Basel See on map Activity type Other Administrative Contact Beat Löffler (Mr.) Links Contact the organisation Opens in new window Website Opens in new window WINZSOFT (ISRAEL) LTD Israel EU contribution € 288 700,00 Address Beit hillel 3 67017 Tel aviv-jaffo See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Avner Levy (Mr.) Links Contact the organisation Opens in new window NANOPET PHARMA GMBH Germany EU contribution € 511 800,00 Address Robert-koch-platz 4 10115 Berlin See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Bianca Grunert (Ms.) Links Contact the organisation Opens in new window Website Opens in new window SEMMELWEIS EGYETEM Hungary EU contribution € 389 800,00 Address Ulloi utca 26 1085 Budapest See on map Region Közép-Magyarország Budapest Budapest Activity type Higher or Secondary Education Establishments Administrative Contact Vilmos Ivády (Dr.) Links Contact the organisation Opens in new window Website Opens in new window BRACCO IMAGING SPA Italy EU contribution € 816 191,00 Address Via egidio folli 50 20134 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Giusy Galgano (Dr.) Links Contact the organisation Opens in new window EDINETHICS LIMITED United Kingdom EU contribution € 105 008,40 Address 1 peinsoraig, uig view hill IV51 9YD Isle of skye See on map Region Scotland Highlands and Islands Lochaber, Skye & Lochalsh, Arran & Cumbrae and Argyll & Bute Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Donald Bruce (Dr.) Links Contact the organisation Opens in new window Website Opens in new window
