Final Activity Report Summary - FLEMING ARRAY+IMAGE (Genomic and imaging approaches to intracellular signaling)
We used these novel methods and approaches to identify and characterize novel genes involved in Drosophila learning and memory with apparent roles in disturbances of these processes in humans. Because of the high functional conservation of genes and functions between Drosophila and humans our results bear directly on improving the human condition. Specifically, genes essential for memory formation and storage were identified that become activated by the gene neuralised whose activity has been implicated in in human sysndromes such as Allagil and Casadil. In addition we have identified a protein that is essential for development of the common learning dissability Neurofibromatosis 1.