Objective In the research part we will deal with the basic principles of the innate immune defense used to control tumors and viral infections with a focus on NK and NK/T cells, including analysis of NK receptor genomics/epigenetics, gene polymorphisms/disease linkage, differentiation of hitherto unrecognized NK cell subpopulations and novel ligands for NK receptors exposed by tumor and/or virally infected cells. We will investigate the mechanisms installed by tumors and viruses to avoid or subvert immune defenses. This will include the investigation of the role of NK/T cell subpopulations in the defense against tumors and infections by herpes virus family members, some being involved intumor formation, in the development of inflammatory diseases and/or constituting a frequent complication during tumor therapy. The project will support anti-tumor and anti-viral therapies by developing novel technology for NK cell generation from cord blood stem cells for NK cell infusions in patients, by genetic engineering of NK cells and by using NK receptors and their ligands to develop novel reagents for amplifying anti-tumor and -viral activities of NK/T cells. It will further undertake basic studies on the potential of the newly emerging iPS cell technology for reconstituting immune systems including NK cells in patients with hematologic cancers.All students of this ITN will be trained in state-of-the-art immunotechnology including wider aspects of molecular medicine at the individual partner universities. An exchange of students between the different partners will be organized to ensure that every participant will be trained in several laboratories/universities with different expertise. It will further include network-wide training modules with cutting-edge lectures of internationally recognized research experts in the field, state-of-the-art seminars in the front-line technologies used in this project as well as courses in genome-wide bioinformatics, business and patent rights. Fields of science medical and health scienceshealth sciencesinflammatory diseasesmedical and health sciencesmedical biotechnologygenetic engineeringmedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicineimmunologyimmunotherapy Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2012-ITN - Marie-Curie Action: "Initial Training Networks" Call for proposal FP7-PEOPLE-2012-ITN See other projects for this call Funding Scheme MC-ITN - Networks for Initial Training (ITN) Coordinator MEDIZINISCHE HOCHSCHULE HANNOVER Address Carl-neuberg-strasse 1 30625 Hannover Germany See on map Region Niedersachsen Hannover Region Hannover Activity type Higher or Secondary Education Establishments Administrative Contact Simone Hess (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 450 214,75 Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT PASTEUR France EU contribution € 515 197,32 Address Rue du docteur roux 25-28 75724 Paris See on map Region Ile-de-France Ile-de-France Paris Administrative Contact Marie-Laure Rosso (Dr.) Links Contact the organisation Opens in new window Website Opens in new window THE HEBREW UNIVERSITY OF JERUSALEM Israel EU contribution € 224 613,84 Address Edmond j safra campus givat ram 91904 Jerusalem See on map Activity type Higher or Secondary Education Establishments Administrative Contact Jane Turner (Ms.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSIDAD POMPEU FABRA Spain EU contribution € 226 681,62 Address Placa de la merce, 10-12 08002 Barcelona See on map Region Este Cataluña Barcelona Activity type Higher or Secondary Education Establishments Administrative Contact Miguel López Botet (Dr.) Links Contact the organisation Opens in new window Website Opens in new window THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution € 285 056,64 Address Trinity lane the old schools CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Administrative Contact Renata Schaeffer (Ms.) Links Contact the organisation Opens in new window Website Opens in new window KING'S COLLEGE LONDON Participation ended United Kingdom EU contribution € 0,00 Address Strand WC2R 2LS London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Paul Labbett (Mr.) Links Contact the organisation Opens in new window Website Opens in new window UCL Elizabeth Garrett Anderson Institute for Women’s Health United Kingdom EU contribution € 285 056,64 Address Gower street WC1E 6BT London See on map Region London Inner London — West Camden and City of London Activity type Higher or Secondary Education Establishments Administrative Contact Malgorzata Kielbasa (Ms.) Links Contact the organisation Opens in new window Website Opens in new window MEDIZINISCHE UNIVERSITAET WIEN Austria EU contribution € 889 734,13 Address Spitalgasse 23 1090 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Administrative Contact Arndt Von Haeseler (Prof.) Links Contact the organisation Opens in new window Website Opens in new window MILTENYI BIOTEC GMBH Germany EU contribution € 222 068,88 Address Friedrich ebert strasse 68 51429 Bergish gladbach See on map Region Nordrhein-Westfalen Köln Rheinisch-Bergischer Kreis Administrative Contact Sabrina Schmitz (Ms.) Links Contact the organisation Opens in new window Website Opens in new window GLYCOSTEM-THERAPEUTICS B.V. Netherlands EU contribution € 236 861,46 Address Kloosterstraat 9 kamer re 1134 5349 AB Oss See on map Region Zuid-Nederland Noord-Brabant Noordoost-Noord-Brabant Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Wim Jongen (Dr.) Links Contact the organisation Opens in new window Website Opens in new window AFFIMED THERAPEUTICS AG Germany EU contribution € 190 800,72 Address In neuenheimer feld 582 69120 Heidelberg See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Michaela Braun (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window
