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Natural Killer Cell-Based Anti-Cancer Immunotherapies:
Research training in molecular medicine and biotechnology business

Obiettivo

In the research part we will deal with the basic principles of the innate immune defense used to control tumors and viral infections with a focus on NK and NK/T cells, including analysis of NK receptor genomics/epigenetics, gene polymorphisms/disease linkage, differentiation of hitherto unrecognized NK cell subpopulations and novel ligands for NK receptors exposed by tumor and/or virally infected cells. We will investigate the mechanisms installed by tumors and viruses to avoid or subvert immune defenses. This will include the investigation of the role of NK/T cell subpopulations in the defense against tumors and infections by herpes virus family members, some being involved in
tumor formation, in the development of inflammatory diseases and/or constituting a frequent complication during tumor therapy. The project will support anti-tumor and anti-viral therapies by developing novel technology for NK cell generation from cord blood stem cells for NK cell infusions in patients, by genetic engineering of NK cells and by using NK receptors and their ligands to develop novel reagents for amplifying anti-tumor and -viral activities of NK/T cells. It will further undertake basic studies on the potential of the newly emerging iPS cell technology for reconstituting immune systems including NK cells in patients with hematologic cancers.
All students of this ITN will be trained in state-of-the-art immunotechnology including wider aspects of molecular medicine at the individual partner universities. An exchange of students between the different partners will be organized to ensure that every participant will be trained in several laboratories/universities with different expertise. It will further include network-wide training modules with cutting-edge lectures of internationally recognized research experts in the field, state-of-the-art seminars in the front-line technologies used in this project as well as courses in genome-wide bioinformatics, business and patent rights.

Invito a presentare proposte

FP7-PEOPLE-2012-ITN
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Coordinatore

MEDIZINISCHE HOCHSCHULE HANNOVER
Indirizzo
Carl-neuberg-strasse 1
30625 Hannover
Germania

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Simone Hess (Dr.)
Contributo UE
€ 450 214,75

Partecipanti (10)

INSTITUT PASTEUR
Francia
Contributo UE
€ 515 197,32
Indirizzo
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15

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Tipo di attività
Research Organisations
Contatto amministrativo
Marie-Laure Rosso (Dr.)
THE HEBREW UNIVERSITY OF JERUSALEM
Israele
Contributo UE
€ 224 613,84
Indirizzo
Edmond J Safra Campus Givat Ram
91904 Jerusalem

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Jane Turner (Ms.)
UNIVERSIDAD POMPEU FABRA
Spagna
Contributo UE
€ 226 681,62
Indirizzo
Placa De La Merce, 10-12
08002 Barcelona

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Miguel López Botet (Dr.)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Contributo UE
€ 285 056,64
Indirizzo
Trinity Lane The Old Schools
CB2 1TN Cambridge

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Renata Schaeffer (Ms.)
KING'S COLLEGE LONDON

Partecipazione conclusa

United Kingdom
Indirizzo
Strand
WC2R 2LS London
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Paul Labbett (Mr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
Contributo UE
€ 285 056,64
Indirizzo
Gower Street
WC1E 6BT London

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Malgorzata Kielbasa (Ms.)
MEDIZINISCHE UNIVERSITAET WIEN
Austria
Contributo UE
€ 889 734,13
Indirizzo
Spitalgasse 23
1090 Wien

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Arndt Von Haeseler (Prof.)
MILTENYI BIOTEC GMBH
Germania
Contributo UE
€ 222 068,88
Indirizzo
Friedrich Ebert Strasse 68
51429 Bergish Gladbach

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Sabrina Schmitz (Ms.)
GLYCOSTEM-THERAPEUTICS B.V.
Paesi Bassi
Contributo UE
€ 236 861,46
Indirizzo
Kloosterstraat 9 Kamer Re 1134
5349 AB Oss

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Wim Jongen (Dr.)
AFFIMED THERAPEUTICS AG
Germania
Contributo UE
€ 190 800,72
Indirizzo
In Neuenheimer Feld 582
69120 Heidelberg

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Michaela Braun (Mrs.)