Objectif The NEURONANO network proposes to integrate carbon nano-tubes (CNT) with multi-electrode array (MEA) technology to develop new generation biochips to help repair damaged central nervous system (CNS) tissues. This objective will be reached by adopting a mul ti-disciplinary approach and by crossing the boundaries among Materials Science, Nano and Micro-technology, and Neuroscience. The impact of carbon nan-otubes on multi-electrode array (MEA) technology and therefore on neuro-implant technology represents a fi rst step toward CNS nanoengineering. Our approach is to push ahead the application and fictionalization of carbon nano-tubes in the CNS by focusing on CNT chemistry, peptide and surface chemistry and two complex networks in cultures: the spinal cord (locomotor networks) and brain (hippocampus and neocortex networks). We will concentrate on the complex electrical activity of these networks once grown on implantable substrates. We are specifically interested in understanding how the components underlying electrical activity are organized when implemented with semi-conductive substrates, and how this organization changes in the presence of molecular cues or chronic stimulations. The research plan has three major aims: i) to answer fundamental questions ab out the biophysical interactions between nano-materials and neurons ii) to exploit carbon nano-tubes in the presentation of positive and negative cues, thus providing specific molecular environment to favour axonal regeneration and retargeting; iii) to deve lop the characterization of novel MEA/nano-tube integrated devices, for multi-site extra-cellular stimulation and recording. Champ scientifique natural sciencesbiological sciencesbiochemistrybiomoleculesnatural sciencesbiological sciencesdevelopmental biologymedical and health sciencesmedical biotechnologytissue engineeringnatural sciencesbiological sciencesneurobiologycomputational neuroscienceengineering and technologyother engineering and technologiesmicrotechnology Programme(s) FP6-NMP - Nanotechnologies and nanosciences, knowledge-based multifunctional materials and new production processes and devices: thematic priority 3 under the 'Focusing and integrating community research' of the 'Integrating and strengthening the European Research Area' specific programme 2002-2006. Thème(s) NMP-2004-3.4.1.2-1 - Using nature as model for new nanotechnology-based processes Appel à propositions FP6-2004-NMP-TI-4 Voir d’autres projets de cet appel Régime de financement STREP - Specific Targeted Research Project Coordinateur UNIVERSITA' DEGLI STUDI DI TRIESTE Contribution de l’UE Aucune donnée Adresse Piazzale Europa 1 TRIESTE Italie Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Participants (5) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France Contribution de l’UE Aucune donnée Adresse Rue Michel-Ange 3 PARIS Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée SZILARDTESTFIZIKAI ES OPTIKAI KUTATOINTEZETE-MAGYAR TUDOMANYOS AKADEMIA Hongrie Contribution de l’UE Aucune donnée Adresse Konkoly Thege u. 29-33 BUDAPEST Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée THE HEBREW UNIVERSITY OF JERUSALEM Israël Contribution de l’UE Aucune donnée Adresse The Hebrew University, Mt Scopus JERUSALEM Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée MULTI CHANNEL SYSTEMS MCS GMBH Allemagne Contribution de l’UE Aucune donnée Adresse Aspenhaustrasse 21 REUTLINGEN Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE Suisse Contribution de l’UE Aucune donnée Adresse Ecublens LAUSANNE Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée