Objective
Infertility is a serious medical concern preventing the parenthood in 10% of couples. Infertility treatment using assisted reproduction techniques (ART) is popular in Europe with up to 5% of children born thanks to medical help. Despite many technological improvements the overall pregnancy rate after infertility treatment using the most commonly practiced in vitro fertilization (IVF) remains only 30% per single cycle. The specific features of human reproduction include the high prevalence of diverse chromosomal pathologies in oocytes and early embryos, and significant dysregulation in gene expression in embryo and endometrial tissue, both being the risk factors for implantation failure and decreased pregnancy rate after IVF. Hence, the intrinsic motivation for the current SARM project stems from the perceived need to contribute to future IVF improvements and benefit from the recent breakthroughs in technological innovations. Our primary research objective is to unravel the molecular nature of human preimplantation embryo development and endometrial maturation. This ambitious goal will be achieved by exploiting highly sophisticated single-cell genomics tools, such as fine-resolution mapping of DNA copy-number changes by using SNP-arrays and sequencing platforms, and characterizing single-cell transcriptional landscape by RNA-sequencing. These studies are likely to propose novel embryonal and endometrial biomarkers useful for selecting the most competent embryos for transfer or identifying the causes of female infertility of endometrial origin. The SARM consortium consists of 2 industrial (IVIOMICS, Paterna/Spain and Competence Centre on Reproductive Medicine, Tartu/Estonia) and 3 academic (Karolinska Institute, Stockholm/Sweden; Katholieke Universiteit Leuven, Belgium and University of Tartu/Estonia) partners, forming a strong, stimulating and coherent research environment ensuring the pooling of complementary scientific skills in reproductive genetics and medicine.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine gynaecology reproductive medicine
- natural sciences biological sciences genetics DNA
- medical and health sciences clinical medicine obstetrics
- medical and health sciences basic medicine pathology
- medical and health sciences clinical medicine embryology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IAPP
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP)
Coordinator
50411 TARTU
Estonia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.