Objective
"The solid form of drug substances (active pharmaceutical ingredients, API) is of huge importance to the European pharmaceutical industry and the European economy, which makes tremendous investments on crystal structure calculation and empirical polymorph screening. Different crystal forms (polymorphs, pseudopolymorphs, salts or co-crystals) have different bioavailability and solubility, and the crystal morphology significantly affects processing and tabletting behaviour. Here, we propose to develop a novel method for identifying, isolation and screening, of new drug solid forms, particularly the production of previously unknown polymorphs by use of chemically and physically tunable supramolecular gels. A gel fiber represents on the local scale an ordered and controllable array of chemical functionality suitable to act as a heteronucleating surface and hence influence the structure of a growing crystal nucleus of a drug polymorph. In well designed cases the API will bind to the gel in such a way that the short-range periodicity within a gel fibril can match up with a complementary face of a precritical nucleus of a particular solid form and hence stabilize that nucleus relative to homogeneous nucleation. Such ‘active’ gels are expected to catalyse the formation of otherwise unstable or hard-to-nucleate solid forms. This proposal aims to use low molecular weight gels as a medium for the templated growth of APIs and to take advantage of the supramolecular nature of these gels in order to dissolve them and hence recover the crystals. The principal objectives are three fold:
(i) Tailor specific gelators to complement the functional groups of target APIs in order to template the growth of novel solid forms by specific solute-gelator molecular recognition.
(ii) Establish reversible gelation condition in order to recover the APIs by dissolving the gels.
(iii) Show by means of relevant case studies that tailored gelators allow the discovery of novel drug solid forms."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering fibers
- engineering and technology materials engineering crystals
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
DH1 3LE DURHAM
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.