Objective
There is ample evidence for important roles of cytokinesis in animal development besides ensuring faithful division of daughter cells. However, these additional functions and their mechanistic basis are not well understood. With the work proposed here we will elucidate roles of cytokinesis in differentiation and tumorigenesis. We will focus on the function of the midbody ring (MR), a protein-dense organelle that forms at the site of abscission during cytokinesis. This organelle forms only once during cell division and thus can only be inherited by one of the two daughter cells, creating an inherent asymmetry to cytokinesis. MRs have been implicated in sequestering stem-cell markers and as mediators of differentiation and pluripotency in vitro, the underlying molecular mechanisms and in vivo functions are not clear.
We propose a multidisciplinary approach that combines microscopy, computational image analysis, and developmental genetics to analyze how asymmetric MR inheritance affects differentiation and tumorigenesis. We will transfer image analysis technology to the host institution that allows us to use Caenorhabditis elegans as a developmental model for automated cell tracking and fate mapping, to quantitatively analyze the function of MRs in development: We will investigate how asymmetric MR inheritance is regulated during C. elegans embryogenesis and tumor formation and how asymmetric MR distribution affects major differentiation decisions. C. elegans is ideally suited for these experiments since we know the entire embryonic cell lineage, all major differentiation decisions, can induce well-defined tumors, and have powerful genetic tools to manipulate development.
We expect that the main results of our work will be of great general interest since they will for the first time address the role of MRs in vivo based on a quantitative approach, thus improving our understanding how asymmetries in cytokinesis can affect normal development and cancer
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences biological sciences developmental biology
- natural sciences physical sciences optics microscopy
- medical and health sciences clinical medicine oncology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
60323 Frankfurt Am Main
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.