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Probabilistic Models in Pseudo-Euclidean Spaces

Obiettivo

Biological sequence databases are a core source of information in the life sciences
and have nowadays grown to multiple thousand entries. Classically, a query of a sequence to such a
database requires the comparison of the query to each entry using an alignment algorithm,
like fasta, smith-Waterman or blast. Many realtime and high-througput experiments rely
on a quick identification of the query to decide the next steps in the experimental pipeline
and are currently slown down by the costs of the classical retrieval systems.
The main objective of this proposal is to provide quick large-scale identification
algorithms in non-metric spaces, induced by the scoring functions for sequence-alignments.
Thereby, the proposal aims on techniques which avoid the full calculations of the scorings
during training and retrieval, employing different mathematical and probabilistic approximation techniques.

Invito a presentare proposte

FP7-PEOPLE-2012-IEF
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Coordinatore

THE UNIVERSITY OF BIRMINGHAM
Indirizzo
Edgbaston
B15 2TT Birmingham
United Kingdom
Tipo di attività
Higher or Secondary Education Establishments
Contributo UE
€ 221 606,40
Contatto amministrativo
May Chung (Ms.)