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Tissue Specific Delivery via Cleavable and Degradable Polymers

Objective

The host group (Professor Bradley of the University of Edinburgh) has worked in the area of polymer chemistry for a large number of years in several different areas, specifically: (i). The development of polymeric microspheres and their application in the cellular delivery of a variety of cargos and (ii). The discovery of polymeric substrates, surfaces and gels that control cellular function. The basis of my proposal is to synergistically combine these two areas of research expertise and generate a family of totally novel new materials with a rich biomedical potential. Concretely the two research areas (i) and (ii) will be brought together but with an added twist – specifically the project will target the generation of polymers and linkers designed to be cleaved or fragmented in the proximity of diseased tissues, cancers or regions of high oxidative stress. The nature of the environment will subsequently trigger the delivery of a cargo; entrapped within the polymer or attached to the linker; into cells or tissues at specific sites of infection, injury or disease, thereby allowing the control or modulation of specific biomedical processes.

Field of science

  • /natural sciences/chemical sciences/polymer science
  • /medical and health sciences/clinical medicine/oncology/cancer

Call for proposal

FP7-PEOPLE-2012-IEF
See other projects for this call

Funding Scheme

MC-IEF - Intra-European Fellowships (IEF)

Coordinator

THE UNIVERSITY OF EDINBURGH
Address
Old College, South Bridge
EH8 9YL Edinburgh
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 221 606,40
Administrative Contact
Angela Noble (Ms.)