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Tissue Specific Delivery via Cleavable and Degradable Polymers

Objectif

The host group (Professor Bradley of the University of Edinburgh) has worked in the area of polymer chemistry for a large number of years in several different areas, specifically: (i). The development of polymeric microspheres and their application in the cellular delivery of a variety of cargos and (ii). The discovery of polymeric substrates, surfaces and gels that control cellular function. The basis of my proposal is to synergistically combine these two areas of research expertise and generate a family of totally novel new materials with a rich biomedical potential. Concretely the two research areas (i) and (ii) will be brought together but with an added twist – specifically the project will target the generation of polymers and linkers designed to be cleaved or fragmented in the proximity of diseased tissues, cancers or regions of high oxidative stress. The nature of the environment will subsequently trigger the delivery of a cargo; entrapped within the polymer or attached to the linker; into cells or tissues at specific sites of infection, injury or disease, thereby allowing the control or modulation of specific biomedical processes.

Champ scientifique (EuroSciVoc)

Programme(s)

Thème(s)

Appel à propositions

FP7-PEOPLE-2012-IEF
Voir d’autres projets de cet appel

Régime de financement

MC-IEF - Intra-European Fellowships (IEF)

Coordinateur

THE UNIVERSITY OF EDINBURGH
Contribution de l’UE
€ 221 606,40
Adresse
OLD COLLEGE, SOUTH BRIDGE
EH8 9YL Edinburgh
Royaume-Uni
Région
Scotland Eastern Scotland Edinburgh
Type d’activité
Higher or Secondary Education Establishments
Liens
Coût total
Aucune donnée