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Tissue Specific Delivery via Cleavable and Degradable Polymers

Obiettivo

The host group (Professor Bradley of the University of Edinburgh) has worked in the area of polymer chemistry for a large number of years in several different areas, specifically: (i). The development of polymeric microspheres and their application in the cellular delivery of a variety of cargos and (ii). The discovery of polymeric substrates, surfaces and gels that control cellular function. The basis of my proposal is to synergistically combine these two areas of research expertise and generate a family of totally novel new materials with a rich biomedical potential. Concretely the two research areas (i) and (ii) will be brought together but with an added twist – specifically the project will target the generation of polymers and linkers designed to be cleaved or fragmented in the proximity of diseased tissues, cancers or regions of high oxidative stress. The nature of the environment will subsequently trigger the delivery of a cargo; entrapped within the polymer or attached to the linker; into cells or tissues at specific sites of infection, injury or disease, thereby allowing the control or modulation of specific biomedical processes.

Campo scientifico (EuroSciVoc)

Argomento(i)

Invito a presentare proposte

FP7-PEOPLE-2012-IEF
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Meccanismo di finanziamento

MC-IEF - Intra-European Fellowships (IEF)

Coordinatore

THE UNIVERSITY OF EDINBURGH
Contributo UE
€ 221 606,40
Indirizzo
OLD COLLEGE, SOUTH BRIDGE
EH8 9YL Edinburgh
Regno Unito
Regione
Scotland Eastern Scotland Edinburgh
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
Nessun dato