Objective
The hydroacylation reaction (HA) is a potentially powerful transformation in organic synthesis. The transformation of an aldehyde and an unsaturated hydrocarbon into a ketone involves the formation of a new C-C bond under atom-economical conditions. The main limitation of this reaction is the possible decarbonylation of one of the reaction intermediates. This research proposal aims the control of this undesirable decarbonylation pathway. This will be achieved by both attenuating decarbonylation and promoting the (rate limiting) reductive elimination step of the final product. With this in mind and taking into account the results recently reported by the host laboratory in the HA field (J. Am. Chem. Soc., 2012, 134, 4885), a new generation of Rh(I) complexes containing small bite angle diphosphine ligands will be employed.
The preparation of a series of small bite angle PXP ligands (X being C, N or B) would allow the study of the effect of the different steric and electronic parameters on the catalytic performance of the Rh(I) complexes. Metal complexes bearing phosphine ligands with different R groups (iPr, tBu, Cy, Ph, etc.), hemilabile phosphine ligands and ligands with suitable hydrophilic functionalities (water-soluble R groups) will be screened under the standard “challenging” HA conditions.
This project will deliver the synthesis of a set general intermolecular HA catalysts that demonstrate high levels of functional group tolerance, stability under catalytic conditions, attractive rates of reaction for demanding substrates, low catalyst loadings with use of minimal and green solvents. By achieving this, we believe that HA will become a general and robust synthetic method for the production of fine and bulk chemicals, new materials and target molecules, rivaling the process of metathesis, hydrogenation, C–C cross coupling and alkene oxidation that are primary disconnections in organic synthetic methodology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences organic chemistry aldehydes
- natural sciences chemical sciences organic chemistry ketones
- natural sciences chemical sciences electrochemistry electrolysis
- natural sciences chemical sciences organic chemistry hydrocarbons
- natural sciences chemical sciences catalysis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
OX1 2JD Oxford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.